异体脱细胞真皮质与珊瑚羟基磷灰石联合修复根尖周组织缺损的临床研究.pdfVIP

摘 要 异体脱细胞真皮基质与珊瑚羟基磷灰石联合修复 根尖周组织缺损的临床研究 研究生：王进涛 导师：钟良军 教授 摘 要 目的：评价异体脱细胞真皮基质与珊瑚羟基磷灰石两种材料联合修复根尖周组 织缺损的临床疗效。方法：选择76 例慢性根尖周炎患者作为研究对象，采用抽签法 随机分为2 组：实验组38 例采用异体脱细胞真皮基质与珊瑚羟基磷灰石联合修复根 尖周组织缺损；对照组38 例不植入任何材料。实验组及对照组均行根尖切除术及根 尖倒充术。术后1 周及6、12 个月复诊，通过临床症状和X 线片检查评价术后疗效。 结果：术后1 个月, 异体脱细胞真皮基质全部存活，因修整瘘管口周围炎性的肉芽组 织导致的牙龈组织缺损已经愈合。在术后12 个月，实验组有效率为94.7%；对照组 有效率为78.9%，经统计学检验，c 2 =4.15, P ＜0.05 ，两者有效率的比较具有统计学 差异。实验组有效病例在术后6 个月骨缺损区阴影基本消失, 珊瑚羟基磷灰石颗粒间 的透射影减小，出现有一定致密度的影像，提示有新骨长入；术后12 个月珊瑚羟基 磷灰石颗粒密度已接近正常的骨组织密度，与正常骨组织之间有密度移行改变，逐 渐与牙槽骨形成骨溶合。结论：异体脱细胞真皮基质与珊瑚羟基磷灰石联合修复根 尖周组织缺损具有良好的临床疗效。 关键词：异体脱细胞真皮基质；珊瑚羟基磷灰石；根尖周组织缺损 — 1— 新疆医科大学医学硕士学位论文 Clinical research of acellular dermal matrix allograft combined with coralline hydroxyapatite in repairing periapical tissue defects Postgraduate:Wang Jin-tao Supervisor: Prof.Zhong Liang-jun Abstract Objective：To evaluate the effects of acellular dermal matrix allograft combined with coralline hydroxyapatite in repairing periapical tissue defects.Methods: 76 cases of chronic apical periodontitis were randomly divided into two groups.In the experimental group (38 cases)which tissue defects were packed with acellular dermal matrix allograft and coralline hydroxyapatite.In the control group(38 cases)which tissue defects were void. Clinical examination and X-ray film after 1 week and 6,12-month follow-up visits to evaluate the effects.Results: After 1 months, all patchs survived, moreover, the defect of gingival tissues that caused by repairing fistula had been healed. After 12 months,the rate of efficiency of the experimental group is 94.7