补肾至仙汤治疗绝经期综合征及对神经—内分泌—免疫网络影响的临床研究.pdfVIP

The Clinical Study on the effect of BuShenZhiXian Decoction in Treating PeriPheral MenoPause Syndrome （PMS ）and Neuroendocrine -Immune Network SPeciality:Gynecology of TCM Author:Wang Xian Tutor:Pro.Liu Jinxing Abstract Objective：To observe the clinical therapeutic effect of BuShenZhiXian Decoction (BSZXD) in treating the deficiency of Kidney-Yin and Kidney-Yang of PMS and explore the mechanism of its effect on Neuroendocrine-Immune Network. Method ：68 Patients with PMS were divided into two groups at random:the test group(34 cases,treated with BSZXD) and the control group(34 cases,treated with Jiarong tablets). Before and after treatment, observe the improvement on the clinical symptoms ， physical signs and determine the changes of E2,FSH,LH,β-EP,NE,5-HT,IL-2.The differences between the two groups are observed. Result ：The markedly clinically effective rate is 73.53% in the test group,and in the control group it is 35.30%;the total clinically effective rate is 94.12% in the test group and it is 76.47% in the control group. The difference between the two groups is significant (P ＜0.05) ；The markedly clinically effective rate of TCM is 79.41% in the test group,and in the control group it is 47.06%;the total effective rate of TCM syndrome is 94.12% in the test group and it is 79.41% in the control group. The difference between the two groups is significant(P ＜0.05);After the treatment,both the Kupperman points and the TCM symptom scores of the treat group and control group are lowered.The differences are significant before and after treatment (P＜0.01). The differences between the two groups are significant(P＜0.05);After treatment, E is raised and FSH,LH are lowered(P ＜0.01)，