- 1、本文档共22页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
- 5、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
- 6、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们。
- 7、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 8、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
Historical Perspectives in the Study of Proteins.ppt
Proteomics in the Context of Thailand Professor M.R. Jisnuson Svasti Center for Excellence in Protein Structure and Function and Dept of Biochemistry, Faculty of Science, Mahidol University Laboratory of Biochemistry, Chulabhorn Research Institute, Bangkok e-mail: scjsv@mahidol.ac.th Roles of Proteins Proteins are the instruments through which the genetic potential of an organism are expressed Proteins are involved in almost all processes of body and fulfil many functions Functions of Proteins enzyme catalysis, transport, mechanical support, organelle constituents, coordinated motion, storage reserves, metabolic control, sensory perception, protection mechanisms, toxins, and osmotic pressure Importance of Studying Proteins Human Genome Data - complete, but does not show how proteins function - or how biological processes occur Proteins sometimes chemically modified after synthesis - Proteolytic cleavage, hydroxylation, oxidation, carboxylation, methylation, acetylation, phosphorylation, glycosylation, transamidation, crosslinkage Proteins also fold into specific three-dimensional structure which determines function Some covalent post-translational modifications Approaches for Study of Proteins Purification, characterisation of properties primary structure Study of molecular mechanism of action - correlation of structure activity – drug design - need 3-D structure - X-ray crystallography (n.m.r. for small mols) Changes in expression and/or properties of proteins - proteomics approach - study all proteins at all states at all times 2-DE Comparison of Proteins from two different conditions Defining proteomics Equipment Available for Research on Protein Structure in Thailand E-mail survey of some 30 departments at different universities Amino Acid Analysis Protein Sequencer 2-D Electrophoresis MALDI/TOF; ESI/MS/MS or MS/MS Circular dichroism, protein NMR Macromolecular X-ray crystallography Computer modelling of protein structure Currently available/ in r
您可能关注的文档
最近下载
- 琴学(内篇一卷外篇一卷)+-+[清]曹庭栋.pdf
- 教学设计《追寻油菜花之旅——探秘中国的气候特征》.docx
- 班主任工作总结ppt课件.pptx
- 破产程序全流程梳理.pptx VIP
- [江西]2023年江西工业贸易职业技术学院人事代理人员招聘笔试历年高频考点(难、易错点)附带答案详解.docx
- 传染病的分类与预防措施课件.ppt VIP
- 16G101图集梁的平法识图.pptx
- 食品健康与安全:推动食品安全产业国际竞争力提升.pptx
- 20230421-东吴证券-保险Ⅱ行业深度报告:寿险定价利率调整,回顾、分析与展望.pdf
- 2024年公共卫生防疫员:防控、调查、疫苗等技能知识试题库必考.docx
文档评论(0)