中心体异常扩增和染色体不稳定性.pdfVIP

生物技术通报 BIO TE CHN OLOG Y B ULLETIN 20 10 2 李智涛 吴逸明 (, 450001) : 中心体作为主要微管组织中心在细胞周期事件中起着重要的作用异常中心体 产生纺锤体异常, 使染色体 错误分离, 引起染色体不稳定性和非整倍体的形成中心体异常同染色体不稳定性一样是肿瘤细胞的一个普遍特征, 并且 出现在肿瘤发生的早期阶段中心体异常在肿瘤的发生发展演化过程中 能具有重要作用现综述中心体的结构功能复 制和调控, 阐述肿瘤中中心体异常的表现和导致中心体扩增的 能机制及中心体扩增与染色体不稳定之间的相关性 : 中心体 染色体不稳定性 非整倍体 肿瘤 Centrosom e Abnorm al Amplification and G enom ic Instability L i Zh itao Wu Y im ing (Dep artm ent of OccupationalH ealth and OccupationalD isease, College of PublicH ealth, Zhengzhou University, Zhengzhou 450001) A bstrac:t Cen trosm e, as onem ain part ofm icrotubu le organ i ing center, play an mi portant role in cell cycles. False sister ch rom a tid separation and chrosom al instability( aneup lo idy) m ay be caused by abnorm al cen trosom e, wh ich may m ake bipolar sp ind le abnor m al. A bnormal centrosom e, as chrosom al instability, is aw idespread characteristic cancer cells. U sually, abnormal centrosom e is found in early stag e of tum or igenesis and play an mi portant role in in itiation, progress ion and evolution of cancer. In th is article, the structure, function, duplication and regu lation of centrosom e was descr ibed, and the expression of abnorm al centrosom e, the po ssib lem echan ism of centrosome amp lification, and the correlation of centrosom e am plification and chrosomal instab ility w ere also explained detailed ly. K ey w ords: Centrosom e Chro som al instability A neup lo idy T um or , , , 20, , , , , , 1 RNA ( RNA interference) , 1887, (