超声龈下刮治同步奥硝唑冲洗治疗牙周炎对牙周组织中骨保护素表达影响的研究.docVIP

超声龈下刮治同步奥硝唑冲洗治疗牙周炎对牙周组织中骨保护素表达影响的研究 　　【摘要】 目的：探讨超声龈下刮治同步奥硝唑冲洗对慢性牙周炎患者的治疗效果及对龈沟液（GCF）中骨保护素（OPG）水平的影响。方法：选取2011年4月-2013年10月在本院诊治的136例慢性牙周炎患者，按照随机数字表法将其分为同步治疗组和对照组，每组各68例。同步组采用超声龈下刮治同步奥硝唑冲洗进行治疗，对照组仅行超声龈下刮治治疗。两组患者分别在治疗前、治疗后4周测量茵斑指数（PI）、探诊出血（BOP）、探诊深度（PD）及附着丧失（AL）等牙周指标和GCF中OPG水平，并进行对比。结果：治疗后4周，两组患者的PI、BOP、PD及AL等牙周指标均明显低于治疗前，OPG明显高于治疗前，RANKL和RANKL/OPG均明显低于治疗前，且同步治疗组以上各指标均明显优于对照组，差异均有统计学意义（P中国论文网 /6/view-7251312.htm 　　【关键词】 超声龈下刮治； 甲硝唑； 牙周炎； 龈沟液； 骨保护素 　　【Abstract】 Objective：To investigate the effect of ultrasonic subgingival scaling and synchronization flushing with Ornidazole in the treatment of chronic periodontitis and it on the influence of osteoprotegerin（OPG） levels in the gingival crevicular fluid（GCF）.Method：136 cases of chronic periodontitis admitted to our hospital from April 2011 to October 2013 were selected and they were divided into the synchronization treatment group and of the control group according to the random number table method，68 cases in each group.The synchronization treatment group was treated with ultrasonic subgingival scaling and synchronization flushing with Ornidazole.The control group was only treated with ultrasonic subgingival scaling.The plaque index（PI），bleeding on probing（BOP），probing depth（PD），attachment loss（AL） and levels of OPG in GCF before treatment，4 weeks after treatment were detected and compared between the two groups.Result：4 weeks after treatment，the periodontal indexes of PI，BOP，PD and AL in the two groups were significantly lower than before treatment，the OPG levels in GCF of the two groups were significantly higher than before treatment，RANKL and RANKL/OPG of the two groups were significantly lower than before treatment，and all above indexes of the synchronization treatment group were significantly better than those of the control group，the differences were statistically significant（P 　　牙周炎发病率高，对患者健康的影响大，其治疗方法和发病原因一直以来都是学者们研究的重点。关于牙周炎的起因以及疾病进展机制的研究已经有了较大的进展，但目前为止还没有得出一致的结论[1]。目前广泛被人们认可的机制是前骨细胞分化为骨细胞的过程被核因子KB受体活化子配体（rece