乙胺吡嗪利福异烟片Ⅱ治疗新发涂阳结核的效果分析.docVIP

乙胺吡嗪利福异烟片Ⅱ治疗新发涂阳结核的效果分析 　　[摘要] 目的 探讨乙胺吡嗪利福异烟片Ⅱ治疗新发涂阳结核患者转涂阴的临床效果。 方法 选择我院2014年1～12月在全国结核病管理信息系统中收治现已结案的并有完整临床及随访资料的新发涂阳结核患者121例纳入研究对象，将其随机分为对照组（n=60）和观察组（n=61）。对照组给予板式组合药HRZE和HR治疗，观察组给予乙胺吡嗪利福异烟片Ⅱ治疗。观察121例患者痰菌转阴情况、病灶吸收情况、不良反应。 结果 治疗2个月末和4个月末时，观察组痰菌转阴率分别为91.8%、96.7%，与对照组的90.0%、93.3%比较，差异无统计学意义（P0.05）；观察组平均转阴时间为（3.1±0.7）个月，与对照组的（3.3±0.6）个月比较，差异无统计学意义（P0.05）。治疗2个月末和4个月末，观察组结核病病灶总吸收率分别为85.2%、91.8%，与对照组的83.3%、90.0%比较，差异无统计学意义（P0.05）。治疗过程中，观察组不良反应发生率为11.5%，对照组为13.3%，两组比较差异无统计学意义（P0.05）。 结论 在新发涂阳结核患者中，免费的乙胺吡嗪利福异烟片Ⅱ治疗效果显著，经济实惠，服用方便，老少皆宜，痰涂转阴和病灶吸收率高，不良反应少。 中国论文网 /6/view-7216633.htm 　　[关键词] 乙胺吡嗪利福异烟片Ⅱ；结核病；转阴 　　[中图分类号] R978.3 [文献标识码] A [文章编号] 1674-4721（2016）02（a）-0129-03 　　Effect analysis of yianbiqinlifuyiyanⅡ in the treatment of new smear positive tuberculosis 　　OUYANG Ai-yu PENG Tao YOU Xiao-ying ZHOU Jian-zhen 　　Department of Public Health，the Third People′s Hospital of Jiujiang City in Jiangxi Province，Jiujiang 332000，China 　　[Abstract] Objective To investigate the clinical effect of smear negative of yianbiqinlifuyiyan Ⅱ in the treatment of new smear positive tuberculosis patients. Methods 121 patients from January to December 2014 in the national tuberculosis management information system were selected and randomly divided into control group（n=60） and observation group（n=61）.The control group was given HRZE and HR plate combination drug therapy，while the observation group was given yianbiqinlifuyiyan Ⅱ.The negative sputum，absorption of lesions，adverse reaction of 121 patients were observed. Results Treatment for 2 months and 4 months，the sputum negative conversion rate of observation group was respectively 91.8%，96.7%，and that was respectively 90.0%，93.3% in the control group，the difference was not statistically significant between two groups（P0.05）.The average clearance time of observation group was （3.1±0.7）months，compared with the control group according for （3.3±0.6） months，the difference was not statistically significant（P0.05）.Treatment for 2 months and 4 mon