乳腺病理基础---组织学(纪小龙).ppt

Breast Cancer: FACTS IN THE USA Incidence 200,000/yr. Deaths 40,000/yr. Stages: DCIS 20% I II 65% III IV 15% 乳腺癌 女性恶性肿瘤首位 （北京、上海、天津） 发病率 20-30/10万 （美国100+/10万） 男性占1% 乳 腺 病 理 发育异常 炎症 增生 肿瘤 良性 恶性 乳线（1月末、9mm） 乳嵴（2月、11.5mm） 乳腺始基（3月、仅一对） 浅筋膜内 2~6肋间 150~200克 由大汗腺衍生而来 多管泡状腺 乳腺脂肪体（脂肪囊） 组织结构要点 乳腺＝性器官。 The best time for breast examination is 5 to 7 days after cessation of menses, when the morphologic influences of hormones are minimal. The Structural Units (Terminal Ductal Lobular Units, TDLU) of the Human Breast The Structural Units (Terminal Ductal Lobular Units, TDLU) of the Human Breast Three-dimensional drawing of dark, spidery myoepithelial cells surrounding sweat gland tubule. By contracting, they help to squeeze out the secretion . Human milk and lactation. Myoepithelial cells, open and contracting. Milk is synthesized in the mammary gland. Within the mammary gland is the milk producing unit, the alveolus. It contains a single layer of epithelial secretory cells surrounding a central storage area called the lumen, which is connected to a duct system. The secretory cells are, in turn, surrounded by a layer of myoepithelial cells and blood capillaries. Mammary lobules from the breast of a young woman of reproductive age and not pregnant (10x). Note the dense interlobular connective tissue stroma, the looser intralobular connective tissue and the mature fat. Note also the dense fibrosis in the smaller lobule and the duct between the two lobules. Unfortunately, this young woman had breast cancer in another portion of the breast and cancer cells can be seen in the lymphatics in the lower right. Mammary lobule from the breast of a young woman of reproductive age and not pregnant. Note the dense interlobular connective tissue stroma and the looser intralobular connective tissue. The basement membrane and the lumenal and myoepithelial cells are observable at this m