《Ultrasensitive Ambient Mass Spectrometric》.ppt

Reporter:Zhou Jiang Liang Date：2016.3.10 Email163.com Literature Reports 东华理工大学化学生物与材料科学学院 Faculty of Biology, Chemistry and Material Science, East China University of Technology Ultrasensitive Ambient Mass Spectrometric Analysis with a Pin-to-Capillary Flowing Atmospheric-Pressure Afterglow Source （Jacob T. Shelley,et al，May 31, 2011, Anal Chem) Department of Chemistry and Center for Analytical Instrumentation Development. IF 5.636 Contents Experimental 1 Background 2 Result and Discussion 3 Conclusion 4 Background The main advantage of the pin-to-Capillary FAPA Directly desorbing/ionizing samples With limits of detection(100 fmol) Less afffected by competitive-ionization Experiment method The electrodes were held in place within a discharge chamber and hole enableed excitedspecies,lastly,for desorption and ionization of analytes . Experimental Figure 1 (a) pin-to-plate FAPA configuration with the discharge chamber constructed from Teflon. (b) pin-to-capillary FAPA with a Mykroy ceramic Figure 2 (a) Positive-ion background mass spectra for the pin-to-plate (b) pin-to -capillary FAPA sources. Figure 3 (a) Negative-ion background mass spectra for the Teflon-bodied, pin-to-plate FAPA and (b)The Mykroy-bodied , pin-to-capillary FAPA. With Both sources (a) Negative-ion background mass spectra for the Teflon-bodied, pin-to-plate FAPA. (b)The Mykroy-bodied, pin-to-capillary FAPA. Figure 4 (a) APGD current and (b) Helium flow rate  Figure 5 Nyquist 尼奎斯 (a) Direct analysis of a bulk solution of 8 μg/ mL terbuthylazine in methanol : water. (b)Chronogram of methamphetamine MS/MS fragments for different concentrations in tap water. Figure 6 Conclusion The FAPA can both generate negative reagent ions directly The FAPA produce high gas temperatures ,enabling direct detection P