《Group-Meeting》.ppt

Group-Meeting Yang-Ping Oct. 8,2015 PLASMA-BASED AMBIENT IONIZATION MASS SPECTROMETRY IN BIOANALYTICAL SCIENCES Marek Smoluch, Przemyslaw Mielczarek, Jerzy Silberring. Accpeted at Dec,2014. Published in Wiley Online Library. Background Introduction 1.Plasma-based ambient ionization MS techniques allow for a wide range of applications. 2.Since 1984, MS has been one of the most important tools in biomedical science. 3.It has several limitations such as complex and time-consuming sample preparation. Derivation Differences between API and ADI Overview and Applications DART (2005 by Cody et al.) 1.The oldest ADI method. 2.The only one of commercially available plasma-based ADI source. Principle: Glow discharge Analysis range: Solid,Gases and liquids. Applictions: Analysis from Clothes,banknotes,fruits,vegetables,drugs and others. Overview and Applications FAPA (2006 by Andrade et al.) 1.The sample is introduced beyond the glow discharge zone 2.A sensitive and reproducible analytical technique. Principle: Glow discharge Analysis range: Solid,Gases and liquids. Applictions: Imaging mass spectrometry Overview and Applications DBDI (2007 by Na et al.) 1.Its detection limit equal to or even better than for APCI. 2.analyzed in natural products with no sample preparation. Principle: Dielectric barrier discharge Analysis range: Solid and liquids. Applictions: Check addictive drugs (cocaine and D 9 -THC) and antibiotics Overview and Applications LTP (2008 by Harper et al.) 1. Allows for the direct interaction of plasma with the sample 2. The temperature of the surface exposed to the plasma beam is ca.30?C Principle: Dielectric barrier discharge Analysis range: Solid,Gases and liquids. Applictions: Ionize biomolecules and pharmaceuticals. Overview and Applications ASAP(2005 by Mcewen et al.)DAPCI (2005 by Cotte-Rodriguez et al.) 1. Possibility for the ionization of both polar and non-polar compounds