降钙素原在发热伴血小板减少综合征与脓毒症鉴别诊断中-安徽医药杂志.docVIP

降钙素原在发热伴血小板减少综合征与脓毒症鉴别诊断中的应用价值 丁振兴 张泓 （安徽医科大学第一附属医院急诊内科，安徽 合肥 230022） 通讯作者：张泓，女，主任医师，硕士生导师，研究方向：急危重症， 电子信箱： zhanghon163.com 摘要: 目的 分析降钙素原及常用炎症指标在发热伴血小板减少综合征和脓毒症中的鉴别诊断价值。方法 选取 2014年1月－2015年10月发热伴血小板减少综合征患者21例、对照脓毒症组21例，测定入院24小时内血清降钙素原浓度及常用炎症指标并进行分析。结果 发热伴血小板减少综合征组降钙素原为(0.43±0.45) ng/ml、C反应蛋白为(30.87±61.41)mg/l；脓毒症组降钙素原为(15.62±23.48) ng/ml、C反应蛋白为(54.51±55.89) mg/l。降钙素原在两组间比较差异有统计学意义，C反应蛋白差异无统计学意义。结论 降钙素原在发热伴血小板减少综合征与脓毒症的早期鉴别诊断有一定的鉴别作用，临床值得推广。 关键词: 发热伴血小板减少综合征；降钙素原；新型布尼亚病毒；脓毒症 Clinical value of procalcitonin in differential diagnosis of severe fever with thrombocytopenia syndrome and sepsis Abstract: Objective To detect the differential diagnostic value of procalcitonin and common inflammatory markers in patients with severe fever with thrombocytopenia syndrome and sepsis. Methods From Jan.2014-to Oct.2015, 21 cases of patients with severe fever with thrombocytopenia syndrome and matched 21 cases of patients with sepsis were enrolled. Concentration of procalcitonin and common inflammatory markers were determined at 24 hours and their correlation was analyzed. Results Procalcitonin content in the severe fever with thrombocytopenia syndrome group was averagely (0.43±0.45) ng/ml, and the c-reactive protein was averagely (30.87±61.41)mg/l . In the sepsis group, the average level of procalcitonin was(15.62±23.48) ng/ml, and the average level of c-reactive protein was(54.51±55.89) mg/l. The procalcitonin levels of patients with sepsis were significantly higher than that in severe fever with thrombocytopenia syndrome group (P0.05), and c-reactive protein levels had no statistical difference among two groups (P0.05). Conclusion Procalcitonin is certainly effective in the early differential diagnosis of severe fever with thrombocytopenia syndrome and sepsis. Hence it can be used widely in clinical practice. Key Words: Severe fever with thrombocytopenia syndrome; Procalcitonin Severe fever with thrombocytopenia syndrome bunyavirus; Sepsis 发热伴