10%20刘芬%20麦星宇disorders%20associated%20with%20G答案.pptVIP

Disorders Associated with GPCRs;Fig.1 Putative membrane tography of G protein coupled receptors;Various types of diseases caused by defective GPCRs;A rod photoreceptor cell;The rhodopsin of cattle;;Thyroid tumor;The third intracellular loop;;The arrow is point to the swell Pic. Take from different state;G protein diseases; G protein is composed of αsubunit，βsubunit and r subunit. Mutation in genes that encode the subunits of het- erotrimeric G protein can also lead to in- herited disorders. The inherited disorders is known as G protein diseases. ;疾病; Three types: G protein remained in the active state; G protein remained in the inactive state; G protein remained in the active –inactive state.;The alteraction in amino acid sequence;One is :; Normally,the endocrine cells of the testes initiate testosterone production at the time of puberty in response to the pituitary hormone LH. The testicular cells of the patients bearing the G protein mutation were stimulated to synthesize cAMP in the absence of the LH ligand, leading to premature synthesis of testosterone and precocious puberty.; The mutation in this same G protein in the cells of the parathyroid glands, which funcation at a temperature of 37 ℃,caused the G protein to remain inactive. The cells of the parathyoid glands could not respond to stimuli that would normally cause them to secrete parathyroid hormone,leading to the condition of Hypoparathyroidism.;Gene polymorphisms;Certain alleles of the gene encoding the β2 adrenergic receptor an increased likeli-hood of developing asthma or high blood pressure.; Identify associations between disease susceptibility and genetic polymorphisms is a current focus of clinical research.;Thank you !