GliomamiR-92b-王坤分析.pptVIP

miR-92b controls glioma malignancy Dr. Kun Wang, Prof. Yirong Wang Department of neurosurgery, SRRSH Hospital Introduction- GBM One of the most common forms of neural malignancy. Median survival of 9-12 months. Poor prognosis. Mechanism? Wnt/β-catenin signaling, NLK and GBM GBM Function as oncogenes or tumor suppressor genes MicroRNA microRNA Wnt/β-catenin signaling Wnt/β-catenin signaling Nemo-like kinase miR-92b ? Objective To identify a concrete mechanism of Wnt/beta-catenin pathway regulation by microRNAs in glioma. Materials and methods Human glioblastoma cell lines: U251, U87