莪术油口服吸收机理及制剂前研究3.docVIP

Table of Contents LIST OF FIGURES vi LIST OF TABLES viii LIST OF ABBREVIATIONS x PREFACE xi ACKNOWLEDGEMENTS xiii CHAPTER 1: Introduction 1 1.1. Zedoary Turmeric Oil 1 1.1.1. Introduction 1 1.1.2. Chemical constituents 1 1.1.2.1. Volatile components 1 1.1.2.2. Non-volatile and other components 3 1.1.2.3. Structures elucidation 3 1.1.3. Pharmacological activities of Zedoary Turmeric Oil 5 1.1.4. Pharmacological activities of active components in Zedoary Turmeric Oil 7 1.1.4.1. Curcumol 7 1.1.4.2. Beta-elemene 8 1.1.5. Pharmacokinetics of Zedoary Turmeric Oil 9 1.1.6. Formulation development of Zedoary Turmeric Oil 10 1.1.6.1. Nanocapsule freeze-dried powder injection 10 1.1.6.2. Hydroxypropyl-beta-cyclodextrin inclusion complex 11 1.1.6.3. Soft-gel capsule 11 1.1.6.4. Dripping-pill 11 1.2. The Caco-2 cell culture model 12 1.2.1. Introduction 12 1.2.2. Transport pathways of intestinal absorption 13 1.2.3. Advantages and disadvantages of Caco-2 cell model 15 1.2.4. Applications of Caco-2 model in drug absorption and metabolism 15 1.2.4.1. Absorption screening 15 1.2.4.2. Absorption mechanism 16 1.2.4.3. Drug metabolism 16 1.2.5. In vitro-in vivo comparisons 17 1.3. Self-emulsifying drug delivery systems (SEDDS) 18 1.3.1. Introduction 18 1.3.2. Mechanism of self-emulsification 19 1.3.3. Excipients of SEDDS 20 1.3.3.1. Oil 20 1.3.3.2. Surfactants 21 1.3.3.3. Co-sulvents 21 1.3.4. Conclusions 22 CHAPTER 2: Analytical methods of Zedoary Turmeric Oil 23 2.1. Materials 23 2.1.1. Chemicals 23 2.1.2. Instruments 23 2.2. Methods 24 2.2.1. Analytical methods of Zedoary Turmeric Oil and its pure compounds 24 2.2.1.1. HPLC analysis of Zedoary Turmeric Oil 24 2.2.1.2. HPLC analysis of individual pure component of Zedoary Turmeric Oil 26 2.2.2. Preformulation study of Zedoary Turmeric Oil 30 2.2.2.1. Determination of proportion of each constituents 30 2.2.2.2. Sample prepration for aqueous solubility determination 31 2.2.2.3. Determination of solubility 31 2.2.2.4. Determination of