米非司酮治疗未破裂型异位妊娠对血HCG值及再次妊娠的影响.docVIP

米非司酮治疗未破裂型异位妊娠对血HCG值及再次妊娠的影响 　　[摘要] 目的 研究米非司酮治疗未破裂型异位妊娠对血清HCG值及再次妊娠的影响。方法 随机选取该院2012年2―10月收治的80例未破裂型异位妊娠患者，抽签随机分为观察组和对照组，两组各40例。观察组服用米非司酮治疗，对照组服用甲氨蝶呤治疗。比较两组血HCG恢复正常值的时间以及再次妊娠成功率。 结果 观察组血HCG指标回归正常水平区间时间（21.2±5.4）d和对照组（29.8±6.4）d相比显著较短，差异具有统计学意义（P0.05）。有意愿妊娠患者再次妊娠成功率观察组93.8%、对照组90.0%均较高，两组相较无明显差异，差异无统计学意义（P0.05）。结论 非司酮治疗未破裂型异位妊娠对降低血HCG值效果显著，对再次妊娠的影响较小。 　　[关键词] 异位妊娠；米非司酮；血HCG；再次妊娠 　　[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742（2015）11（b）-0110-02 　　[Abstract] Objective To study the effect of mifepristone in the treatment of non-ruptured ectopic pregnancy on HCG value and re-pregnancy. Methods 80 cases of patients with non-ruptured ectopic pregnancy who were admitted into the hospital during February 2012 to October 2012 were selected and were randomly divided into the observation group and the control group with 40 cases in each group. The observation group took mifepristone for treatment while the control group took methotrexate for treatment. The time of blood HCG recovering to the normal range and the success rate of re-pregnancy was compared between the two groups. Results The time of blood HCG recovering to the normal range in the observation group was （21.2±5.4）d which was significantly shorter than（29.8±6.4）d in the control group and the difference was statistically significant （P0.05）. The success rates of re-pregnancy for patients who were willing to have re-pregnancy were 93.8% in the observation group and 90.0% in the control group which were relatively higher. The comparison between the two groups was not statistically significant（P0.05）. Conclusion Mifepristone in the treatment of non-ruptured ectopic pregnancy has significant effect on reducing the blood HCG value and less effect on re-pregnancy. 　　[Key words] Ectopic pregnancy； Mifepristone； Blood HCG； Re-pregnancy 　　异位妊娠即宫外孕，是受精卵在子宫腔外着床的异常妊娠过程，以输卵管妊娠最为常见，输卵管管腔或周围的炎症易引起管部分堵塞，阻碍受精卵顺利进入子宫而只能在输卵管管内着床发育，严重时极易导致流产和管腔破裂，并由此可分为破裂异位妊娠和未破裂异位妊娠[1]。随着治疗手段的不断进步，治疗方法由以往单一的手术治疗变为手术、药物等多种手段，其中常见药物有米非司酮、甲氨蝶呤、系列中药等[2]。