前列地尔联合复合辅酶治疗急性肾损伤的疗效探讨.docVIP

前列地尔联合复合辅酶治疗急性肾损伤的疗效探讨 　　[摘要]目的 探讨前列地尔联合复合辅酶治疗急性肾损伤的疗效。方法 运用回顾性研究分析进行血液净化的急性肾损伤患者临床资料，按治疗方案不同分为3组，对照组14例，支持对症及病因治疗，前列地尔组16例，在对照组基础上予以前列地尔治疗，联合组12例，在前列地尔组基础上予以复合辅酶治疗，记录治疗前，治疗1周，2周肾功能，28 d脱离血透率和肾功能完全恢复率。结果 治疗后1周，联合组尿素氮、肌酐下降最明显，对照组比较差异有统计学意义（P0.05），治疗后2周，联合组下降最明显，其次前列地尔组，3个组间两两比较均差异有统计学意义（P0.05），28 d脱离透析率： 前列地尔、联合组均比对照组高，差异有统计学意义（P0.05）。28 d肾功能完全恢复率：联合组比对照组、前列地尔组均高，差异有统计学意义（P0.05）。结论 在血液净化基础上，前列地尔治疗急性肾损伤有一定疗效，联合复合辅酶，疗效更好。 　　[关键词] 前列地尔；复合辅酶；急性肾损伤 　　[中图分类号]R59 [文献标识码]A [文章编号]1674-0742（2015）04（b）-0110-02 　　The Protective Effects of Alprostadil Combined with Coenzyme Complex in Treatment of Acute Kidney Injury 　　JIAO Wenwen，TAN Yixiang，TANG Guangrong，DENG Jianlong，XIANG Jinhua 　　Department of Nephrology，The Third Hospital of Changsha city，Changsha，Hunan Province，410001，China 　　[Abstract] Objective To investigate the protective effects of alprostadil combined with coenzyme complex in treatment of acute kidney injury （AKI）.Methods Using a retrospective analysis of clinical data of acute kidney injury patients who received blood purification. According to the therapy， there were 3 groups， control group with 14 cases： besides blood purification ，patients received supportive and symptomatic therapy as well as etiological treatment as the base； alprostadil group with 16 cases， adding alprostadil in the treatment； combination-therapy group with 12 cases ，adding alprostadil combined with coenzyme complex in the treatment.The value of renal function detected before and 1 week，2 weeks after treatment start were recorded， and on the 28th day the rate of patients who didn’t need hemodialysis and had renal function recovered fully were also recorded. Results After 1 week treatment， urea nitrogen and creatinine of combination-therapy group decreased most obviously，compared with control group， the difference was statistically significant （P 　　[Key words] Alprostadil；Coenzyme complex；Acute kidney injury 　　急性肾损伤（AKI）依然是当今临床医学的主要问题，住院各科患者均可发生，也常出现临床急，重，危症，引起严重后果，增加巨额医疗费用负担。虽然我们