精神分裂症患者非酶类抗氧化分子水平的研究.docVIP

精神分裂症患者非酶类抗氧化分子水平的研究 　　[摘要] 目的 观察精神分裂症患者非酶类抗氧化分子水平，探讨精神分裂症发病机制与氧化应激的相关性。 方法 选择2014年6～12月在上海市徐汇区精神卫生中心住院的57例急性期精神分裂症患者和56例慢性期精神分裂症患者为研究对象，检查患者非酶性抗氧化物（血清胆红素、谷酰转肽酶、尿酸及白蛋白）水平，使用阳性和阴性症状量表（PANSS）评估患者的精神症状，比较非酶性抗氧化物在急性期与慢性期的差异及分析其与精神症状的相关性。 结果 急性期与慢性期患者性别及文化程度比较，差异无统计学意义（P 0.05）；急性期与慢性期患者婚姻、职业、年龄、首发年龄及病程比较，差异有统计学意义（P 0.05）。患者血清胆红素与阳性量表、一般精神病理量表、PANSS、思维障碍、激活性及偏执呈正相关（P 0.05）。 结论 精神分裂症急性期的抗氧化能力较慢性期增强，且抗氧化剂与阳性量表和精神病理症状呈正相关。 　　[关键词] 精神分裂症；氧化应激；非酶类抗氧化分子 　　[中图分类号] R749 [文献标识码] A [文章编号] 1673-7210（2015）10（a）-0051-04 　　Study on non-enzymatic antioxidant molecular level of patients with sch-izophrenia 　　WU Yujie1 LI Jun1 CHEN Shuyi1 LI Chenhu1 ZHAN Guilai1 WU Yan2 　　1.Mental Health Center of Xuhui District in Shanghai City， Shanghai 200232， China； 2.Affilited Mental Health Center of Shanghai Jiaotong University School of Medicine， Shanghai 200030， China 　　[Abstract] Objective To observe non-enzymatic antioxidant molecular level of patients with schizophrenia and to investigate the correlation of pathogenesis and oxidative stress of schizophrenia. Methods 57 cases of patients with acute schizophrenia and 56 cases of patients with chronic schizophrenia treated in Mental Health Center of Xuhui District in Shanghai City from June to December 2014 were selected as research objects. Non-enzymatic antioxidant （serum bilirubin， glutamyl endopeptidase， uric acid and albumin） levels of patients were checked， psychiatric symptoms of patients were assesed by PANSS， non-enzymatic antioxidants differences between acute and chronic phase were compared and their correlation with psychiatric symptoms were analyzed. Results Gender and culture in acute stage and chronic stage were compared， with no statistical differences （P 0.05）. Marriage， occupation， age， starting age and course of disease in acute stage and chronic stage were compared， with statistical differences （P 0.05）. Serum bilirubin was positively correlated with positive scale， general spirit of the scale， PANSS， thought di