结缔组织病合并肺动脉高压的临床研究.docVIP

结缔组织病合并肺动脉高压的临床研究 　　【摘要】 目的：研究分析结缔组织病（CTD）伴发肺动脉高压的临床特点以及预后的因素，并讨论其临床意义。方法：选取2012年1月1日-2015年1月1日本院200例结缔组织病患者的临床资料，将未伴发肺动脉高压的患者作为CTD组（100例），伴发肺动脉高压的患者作为CTD-PAH组（100例），回顾性分析两组患者的临床指标，总结、比较两组患者的临床表现、血清免疫学指标及血清自身抗体等实验室指标。结果：两组在心包积液、胸腔积液、肺间质病变、多关节炎、雷诺现象等临床表现上比较差异均有统计学意义（P0.05）；两组在C3、C反应蛋白（CRP）、循环免疫复合物（CIC）和血沉（ESR）等指标上比较差异均有统计学意义（P0.05）；两组在ANA、抗U1RNP抗体阳性等指标上比较差异有统计学意义（P0.05）；CTD组的不良预后比（2.00%）低于CTD-PAH组（15.00%），差异有统计学意义（P0.05）。结论：结缔组织病伴发肺动脉高压的患者中常见心包积液、胸腔积液、肺间质病变、多关节炎、雷诺现象，且CIC升高、抗U1RNP抗体阳性等部分实验室指标具有特征意义，有助于临床的早期诊断。 　　【关键词】 结缔组织病； 肺动脉高压； 临床研究； 预后因素 　　Study on Clinical Features and Prognosis Factors of Tissue Disease Pulmonary Hypertension Disease/WANG Chun-hua.//Medical Innovation of China，2015，12（15）：067-070 　　【Abstract】 Objective：To research and analyze the clinical effect and prognostic factors of tissue disease pulmonary hypertension disease，and discuss its clinical significance.Method：The clinical data of 200 connective tissue who admitted in our hospital from January 2012 to January 2015 were selected， 100 non pulmonary hypertension disease patients were chose as CTD group（100 cases），and 100 pulmonary hypertension disease patients were selected as CTD-PAH group（100 cases）.The clinical index of two groups were analyzed， two group’s clinical symptom，serum immunology auto-antibodies were summarized and compared.Result：Pericardial effusion， pleural effusion， interstitial lung disease， arthritis， renault phenomenon of CTD-PAH group had statistical significance compared with CTD group（P0.05）； CTD-PAH group’s C3， C-reactive protein， circulating immune complex， blood sedimentation had statistical significance compared with CTD group （P0.05）；CTD-PAH group’s ANA ，anti-U1RNP antibody had statistical significance compared with CTD group （P0.05）.The adverse outcome rate of CTD group was lower than that of the CTD-PAH group（P0.05）.Conclusion：Pericardial effusion，pleural effusion，interstitial lung disease，arthritis，renault phenomenon are common in tissue disease combined pu