维生素D与胰岛细胞功能关系的研究进展.docVIP

维生素D与胰岛细胞功能关系的研究进展 　　[摘要] 维生素D是经典的钙磷代谢调节剂。胰岛素抵抗与胰岛β细胞功能受损引起胰岛素分泌缺陷和合成异常是2型糖尿病发病机制的主要特点。近年来国内外越来越多的研究表明，维生素D与2型糖尿病之间关系密切；许多基础研究和动物实验显示维生素D在糖尿病的发生发展过程中发挥着改善胰岛素抵抗、保护胰岛细胞以及调节人体免疫功能的作用。维生素D主要可通过以下3种方式来调控胰岛功能：抑制胰岛β细胞凋亡、促进胰岛β细胞分泌和削弱胰岛α细胞分泌。本篇文章就近年来维生素D与胰岛β细胞功能的相关性研究方面作一综述。 　　[关键词] 维生素D；维生素D受体；2型糖尿病；胰岛细胞功能 　　[中图分类号] R587.1 [文献标识码] A [文章编号] 1673-9701（2015）12-0157-04 　　Advanced on the relationship between vitamin D and islets function 　　ZHONG Lidi1 CHI Lianxiang2 NIE Lei3 NIE Bensui4 WAN Jiejun5 　　1.Guangdong Medical College in Guangdong Province， Zhanjiang 524023， China； 2.Department of Endocrinology， Bao’an Peoples Hospital of Shenzhen City in Guangdong Province， Shenzhen 518101， China；3.Department of Endocrinology， Nanshan District Peoples Hospital of Shenzhen City in Guangdong Province， Shenzhen 518000， China； 4.Department of General Surgery， Baoan Peoples Hospital of Shenzhen City in Guang dong Province， Shenzhen 518101， China； 5.Department of Endocrinology， Taiping Peoples Hospital of Dongguan City in Guangdong Province， Dongguan 523900， China 　　[Abstract] Vitamin D is classic metabolism regulator of the calcium and phosphorus. Type 2 diabetes is main characterized by insulin resistance and beta cell function impairment， which causes insulin secretion defects and synthesis abnormality. In recent years， studies found close relationship between vitamin D and type 2 diabetes； Many basic researches and animal experiments show that vitamin D can improve insulin resistance， protect islet beta cells and have immune regulation effects in the development of type 2 diabetes Diseases. Vitamin D can regulate and control islet function by inhibiting islet beta cell apoptosis， promoting the secretion of pancreatic beta cells and weakening the secretion of islet alpha cell. This paper reviewed the research progress in recent years on the correlation between vitamin D and islets function. 　　[Key words] Vitamin D； Vitamin D receptor； Diabetes； Islets function 　　调节人体内的钙磷代谢过程