该院手足口病标本病毒检测结果观察.docVIP

该院手足口病标本病毒检测结果观察 　　[摘要] 目的 探讨该院手足口病标本病毒检测结果观察。 方法 回顾性分析2014年4―7月在该院治疗的300例手足口病患者的临床资料，分别采用咽拭子标本和粪便标本进行病原学检测，分析检测结果。 结果 所有患者中，肠道病毒（EV）检出率为90.67%，其中肠道病毒71型（EV71）占62.13%，柯萨奇病毒A16（CA16）占16.18%，其他EV亚型占21.69%；粪便标本EV71检出率高于咽拭子标本，差异有统计学意义（P0.05）；男女比例无明显差异，发病主要集中在1～3岁，达76%，尤以1岁内发病率最高，达48.67%。 结论 手足口病由感染EV引起，以EV71和CA16最为高发，粪便标本的检出率更高，加强EV71和CA16的检测有助于提高手足口病的防范和控制。 　　[关键词] 手足口病；标本病毒检测；结果观察 　　[中图分类号] R725 [文献标识码] A [文章编号] 1674-0742（2015）08（b）-0028-02 　　[Abstract] Objective To investigate the virus detection results of specimens of hand， foot and Mouth. Methods The clinical data of 300 cases with hand， foot and mouth disease which were treated in our hospital during April 2014 to July 2014 were retrospectively analyzed， the throat swab specimens and the stool specimens were respectively used to detect the pathogen， and the results were analyzed. Results All patients， the enterovirus （EV） detection rate was 90.67%， the type of enterovirus 71 （EV71） accounted for 62.13%， coxsackie virus A16 （CA16） accounted for 16.18%， other EV subtype accounted for 21.69%； Stool specimens EV71 detection rate was higher than pharyngeal swab specimens， the difference was statistically significant （P 0.05）； Ratio of male to female was not significant difference， mainly concentrated in 1 to 3 years old， the incidence was up to76%， especially within 1 year of age， up to 48.67%. Conclusion Hand， foot and mouth disease caused by infection with EV， EV71 and CA16 were the highest， and the feces specimen detection rate was higher， the detection of EV71 and CA16 was helpful to improve the prevention and control of hand foot mouth disease. 　　[Key words] Hand， foot and mouth disease； Specimens of virus detection； Results observed 　　手足口病是临床常见的传染病，由肠道病毒感染引起，其主要特征表现为发热、手、足、口腔等部位发生皮疹、疱疹或疱疹性咽峡炎，以儿童最为多见[1]。该病多数病情较轻微，预后良好，也有少部分患者病情险恶，可并发无菌性脑膜炎、脑干脑炎、心肌炎等严重疾病，导致死亡[2]。该病的传染性强、传播速度快、传播途径多，可在短时间内造成大范围流行，因此，及时掌握手足口病的病原体、流行特征等对于控制其传播，阻止病情进展，减少危重病例有积极的作用。该研究通过对该院2014年4―7月手足口病标本病毒检测，旨在为临床的防治提供建议，现报道如下。 　　1 资料与方法