辛伐他汀对急性脑梗死患者血清CRP及IL―6水平的影响探讨.docVIP

辛伐他汀对急性脑梗死患者血清CRP及IL―6水平的影响探讨 　　【摘要】 目的：研究分析急性脑梗死患者采用辛伐他汀治疗后血清白细胞介素-6（IL-6）以及血清C-反应蛋白（CRP）的水平变化情况。方法：选取2013年3月-2014年9月在本院就诊的60例急性脑梗死（ACI）患者随机分为治疗组和对照组，每组各30例患者。治疗组在常规综合对症治疗基础上配合辛伐他汀治疗，对照组单独采用常规综合对症处理，分别采用速率散射比浊法、放射免疫分析法测定两组患者治疗前后CRP及IL-6水平变化。结果：治疗组治疗总有效率为90%，对照组治疗总有效率为70%，治疗组治疗总有效率较对照组明显偏高，两组比较差异有统计学意义（P0.05），经相应治疗后两组患者IL-6、CRP水平较治疗前均有所下降，差异有统计学意义（P0.05），但是治疗组患者治疗后IL-6、CRP水平均低于对照组，差异有统计学意义（P0.05）。结论：急性脑梗死患者采用辛伐他汀治疗的临床效果显著，可有效降低患者血清IL-6及CRP水平，抗炎效果较好。 　　【关键词】 急性脑梗死； 辛伐他汀； 血清IL-6； 血清CRP； 影响分析 　　【Abstract】 Objective：To analyze the patients with acute cerebral infarction after simvastatin treatment using serum interleukin-6（IL-6）， and serum C-reactive protein （CRP） level changes in circumstances。Method：60 patients of acute cerebral infarction （ACI） in our hospital were selected from March 2013 to September 2014，and randomly divided into treatment group and control group，30 cases in each group.The treatment group was treated in the routine based on symptomatic treatment with simvastatin，the control group was treated by conventional integrated symptomatic treatment alone.Before and after treatment，the rate nephelometry and radioimmunoassay were respectively used to measured the groups’ CRP and IL-6 levels.Result：The total effective rate of treatment group was 90%，the total effective rate of control group was 70%， the total efficiency of the treatment group compared with the control group was significantly higher，the difference was statistically significant（P0.05）；after treatment， the patients via the corresponding IL-6 and CRP levels were decreased compared with before treatment，the difference was statistically significant （P0.05），but the treatment group’s patients with IL-6 and CRP levels were lower than the control group， the difference was statistically significant comparison（P0.05）.Conclusion：In patients with acute cerebral infarction using simvastatin has significant clinical effect， can effectively reduce serum levels of IL-6 and CRP， anti-inflammatory effect