帕罗西汀联合小剂量奥氮平治疗老年抑郁症的临床观察.docVIP

帕罗西汀联合小剂量奥氮平治疗老年抑郁症的临床观察 　　doi：10.3969/j.issn.1007-614x.2014.22.45 　　摘要目的：探讨帕罗西汀联合小剂量奥氮平治疗老年抑郁症的临床疗效和安全性。方法：66例抑郁症患者随机分成研究组和对照组，研究组给予帕罗西汀合用奥氮平治疗，对照组单用帕罗西汀治疗。共观察8周，于治疗前和治疗后1周、2周、4周、8周末采用汉密尔顿抑郁量表（HAMD）、汉密尔顿焦虑量表（HAMA）评定疗效。采用治疗中需处理的不良反应症状量表（TESS）评定安全性。结果：帕罗西汀合用小剂量奥氮平疗效显著，研究组与对照组的显效率分别为75.0%和51.5%，差异有统计学意义（P0.05）。结论：帕罗西汀合用小剂量奥氮平治疗抑郁症和焦虑症起效快，可提高疗效。 　　关键词奥氮平；帕罗西汀；抑郁症 　　Clinical observation of paroxetine combined with small dose of olanzapine in the treatment of senile depression 　　Qiao Zeguo，Guo Caie，Zhang Yuying，Liu Caiyun，Wu Enhai，hou Haixia，Gao Yunxiang 　　Department of Psychiatry， East District of The First Hospital of Handan City，Hebei（Original Hospital of Integrated Traditional and Western of Handan City），056001 　　AbstractObjective：To investigate the clinical efficacy and safety of paroxetine combined with olanzapine in the treatment of senile depression.Methods：66 cases with depression were randomly divided into the study group and the control group.The study group were treated with paroxetine combined with olanzapine.The control group were only treated with paroxetine.They were observed for 8 weeks.We assessed the efficacy by the Hamilton Depression Scale（HAMD），Hamilton Anxiety Scale（HAMA） before and after the treatment of 1 week，2 weeks，4 weeks，8 weeks.We assessed the safety by the Treatment Emergent Symptom Scale（TESS）.Results：The curative effect of paroxetine with small dose of olanzapine is significantly.The significant efficiency rate of the study group and the control group were 75% and 51.5% respectively.There was significant difference（P0.05）.Conclusion： Paroxetine Combined with olanzapine in the treatment of depression and anxiety has a rapid onset.It can improve curative effect. 　　Key wordsOlanzapine；Pa Rossi Dean；Depression 　　老年抑郁症是老年期常见的情绪障碍，国内文献报道大城市社区老年人抑郁症检出率11.5%[1]，随着我国人口老龄化的加速，老年抑郁症已引起人们的高度关注。探讨老年期抑郁症的治疗一直是精神科医生关注的焦点之一。有研究报道，小剂量非典型抗精神病药对抗抑郁药有增效作用[2-3]，本研究就是为了比 　　较帕罗西汀联合小剂量奥氮平与单独使用帕罗西汀治疗老年期抑郁症的疗效，并观察用药治疗过程中的不良反应，现报告如下。 　　资料与方法 　　2012