射干地龙颗粒对鸡的亚慢性毒性试验.docVIP

射干地龙颗粒对鸡的亚慢性毒性试验 　　摘要：为研究射干地龙颗粒的安全性，将120只21日龄的三黄肉鸡，随机分为3倍剂量组、6倍剂量组、12倍剂量组和对照组，观察射干地龙颗粒对鸡的心、肝、脾、肺、肾脏和血液等组织的影响。结果表明，各组鸡的体重、脏器指数以及血常规指标组间差异总体不显著（P0.05），血清丙氨酸氨基转移酶活性及肌酐含量与药物剂量间呈现无规律性变化，白蛋白含量和尿素含量与对照组差异不显著（P0.05）。在用药后，各组鸡的心、肝、脾、肺和肾脏均无明显差异，表现正常。 　　关键词：射干地龙颗粒；鸡；亚慢性毒性；生理生化指标 　　中图分类号：S858.31 文献标识码：A 文章编号：0439-8114（2013）04-0878-05 　　Study on Subchronic Toxicity of Shegan Dilong Particles in Chicken 　　WANG Gui-bo1，WANG Dong-sheng1，XIE Jia-sheng1，ZHENG Ji-fang1，LUO Chao-ying1，LI Jin-yu1， 　　LUO Yong-jiang2，XIN Rui-hua2，LI Xiao-rong3 　　（1.Lanzhou Institute of Husbandry and Pharmaceutical Sciences， Chinese Academy of Agricultural Sciences，Lanzhou 730050，China； 　　2.Key Laboratory of Veterinary Pharmaceutical Development， Ministry of Agriculture，Lanzhou 730050，China； 　　3.Institute of Livestock Grass and Green Agriculture， Gansu Academy of Agricultural Sciences，Lanzhou 730070，China） 　　Abstract： In order to evaluate the safety of Shegan Dilong particles， 120 21-day-old Sanhuang broilers were randomly divided into four groups including the 3-fold dose group， 6-fold dose group， 12-fold dose group and the control group. The impact on the chicken’s heart， liver， spleen， lung， kidney and blood were observed. The results showed that the difference of overall weight， organ index and blood indicators in each group of chicken was not significant（P0.05）， while there was no regularity between the serum alanine aminotransferase activity， creatinine concentration and drug dosage of each group while the content of albumin and urea had no significant differences compared with the control group（P0.05）. After administration， the performance of chicken’s heart， liver， spleen， lung and kidney were not significantly different from normal in all groups. Key words： Shegan Dilong particles； chicken； subchronic toxicity； physiological and biochemical indexes 　　随着鸡群养殖的集约化程度越来越高，鸡呼吸道疾病成为当前养鸡业中具有严重危害的一类疾病，造成了巨大的经济损失，而且还影响了相关产品的品质。目前鸡呼吸道疾病的治疗多采用疫苗紧急免疫或者西药治疗，而疫苗免疫具有免疫失败的潜在危险性，西药治疗又极易产生细菌耐药性。中药治疗则避免