Chapter5IntrductiontoEfferentNervoussystem.ppt

pharmacology General introduction Drugs acting on efferent nervous system Drugs acting on central nervous system Drugs acting on cardiovascular system Drugs acting on viscera Chemotherapeutic agents Chapter 5 Intrduction to Pharmacologyof Efferent Nervous System Zhang Bin Institute of Pharmacology School of Medicine Shandong University Organization of Nervous system efferent nervous system (ENS) autonomic nervous system (vegetative nervous system) somatic motor nervous system Efferent neurons of the autonomic nervous system Classification of ENS according to the released neurotransmitters cholinergic nerve: acetylcholine (Ach) noradrenergic nerve: noradrenaline ( NA) Section 1 Neurotransmitter and  Receptor of ENS Neurotransmitter of ENS The receptors of ENS 一. Neurotransmitter of ENS 1.Development of neurotransmitter theory 100 years ago Chemical transmission electronic transmission 1946 Von Euler NA (noradrenaline) 1921 loewi double frog heart experiment 1926 Dale Ach (acetylcholine) 2.Biosynthesis, storage, release and termination of neurotransmitters Ach (acetylcholine) NA (noradrenaline) 2.Biosynthesis, storage, release and termination of neurotransmitters (1)Biosynthesis choline + acetyl coenzymeA Ach tyrosine dopa DA NA (2) Storage +ATP+protein store in vesicles (3)release exocytosis quantal realease cotransmission (4)Termination Ach: acetylcholinesterase (AchE) in synapse NA: uptake1 (neuronal uptake ) 75%-90% storage in vesicles\ MAO uptake2(non-neuronal uptake) COMT\MAO 二. The receptors of ENS Classification, Distribution and Effect Choline receptors (Cholinoceptors ) M-R: muscarine N-R: nicotine Cholinoceptors M-R: M1-R: ganglion, CNS M2-R: heart, presynaptic sites (negative fee