核苷类药物抗乙肝病毒的合理用药研讨.ppt

ADV, adefovir; ETV, entecavir; IFN, interferon; LAM, lamivudine; LdT, telbivudine; PegIFN alfa-2a, peginterferon alfa 2a. TDF, tenofovir disoproxil fumarate. There are currently 7 US Food and Drug Application (FDA)–approved medications available for the treatment of chronic hepatitis B. Interferon?alfa, approved in the early 1990s, is given either daily or every other day. In 1998, lamivudine was approved, marking the beginning of the new era of oral therapy. The timeline continues with the approval in 2002 of adefovir, followed by both entecavir and peginterferon alfa 2a in 2005. In 2006, tel