2016李辉读书报告.pptVIP

Metabolic Syndrome and Hepatocellular Carcinoma Li Hui Abby B. Siegel, Andrew X. Zhu. Cancer December 15, 2009,5651-5661.Review Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd. Background Hepatocellular carcinoma (HCC) is the most rapidly increasing cause of cancer death in the United States. Although many risk factors for HCC are well defined, including hepatitis B virus (HBV),hepatitis C virus (HCV), and alcohol, most series have indicated that 5% to 30% of patients with HCC lack a readily identifiable risk factor for their cancer. Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd. Metabolic syndrome Metabolic syndrome is a constellation of problems that includes obesity, dyslipidemia, diabetes, and insulin resistance. FIGURE 1. Components of the metabolic syndrome are shown. NAFLD indicates nonalcoholic fatty liver disease. Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd. Metabolic syndrome Nearly 25% of the US population meets criteria for the metabolic syndrome, and US obesity rates (body mass index [BMI] 30kg/m2) currently also exceed 25% in most regions of the country. Up to 75% of obese adults will develop fatty liver disease. Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd. NAFLD and NASH Nonalcoholic fatty liver disease(NAFLD) is characterized by hepatic steatosis in the absence of a history of significant alcohol use or other known liver disease. Nonalcoholic Steatohepatitis(NASH) is a progressive form of NAFLD and includes inflammatory components on pathology. The NASH Clinical Research Network designed and validated a pathologic scoring system for NASH that is the sum of measures of steatosis, lobular inflammation, and hepatocellular ballooning. Evaluation only. Created with