PKPD在指导抗生素应用_培训课件.pptVIP

美平0.5g q8h, iv 60min和美平1g, q12h, iv 60min对较耐药细菌，其%TMIC是不够的。 4种给药方案对于MIC=4mg/L时的%TMIC，基本都可以达到40%TMIC。 Again, I’ll talk about Monte Carlo simulation, what kinds of data need for it. One is PK distribution data calculated from Meropenem blood concentration trend and another one is Meropenem MIC distribution data against bacterial species. Monte Carlo simulation uses that data in combination and so generates %TMIC distribution. Then, as the result, Monte Carlo simulation show us the probability of target attainment. The more specific simulation process is the next. After I set all parameter, I