肝组织学逆转能否实现 详解.ppt

Fibrosis is a consequence of almost all chronic liver diseases predominantly arising from viral, alcohol-induced, autoimmune, and metabolic aetiologies. It describes the result of a dysregulated wound healing response driven by iterative injury and resulting in the balance of extracellular matrix turnover favouring net deposition. Iterative injury is vital in perpetuating this response. The progressive accumulation of matrix ultimately leads to the development of cirrhosis in a proportion of patients with associated important clinical sequelae. A common pathological feature of chronic liver d