drugsforchf-汕头大学医学院-DrugsforCongestiveHeart.pptVIP

Drugs for Congestive Heart Failure BACKGROUND DEFINITION:The inability of heart to meet the needs of peripheral systems. PATHOGENY:myocardium contraction heart load SYMPTOMS: weakness, fatigue and dyspnea, cyanosis, edema .Change of myocardial structure in CHF Apoptosis Extracellular matrix(ECM)fibrosis Myocardial hypertrophy and remodeling. Change of myocardial function in CHF Systolic dysfunction actin-troponin-tropomyosin system ATP Ca-excitation-contraction-coupling Diastolic dysfunction compliance Change of neural-endocrine system in CHF sympathetic nerve system activation renin-