降钙素原检测在胎膜早破患者中的临床应用价值探讨.docVIP

降钙素原检测在胎膜早破患者中的临床应用价值探讨 　　[摘要] 目的 探讨血清降钙素原检测在胎膜早破患者的临床应用价值。 方法 选择胎膜早破患者（实验组）和正常分娩组（对照组）各180例，采用电化学发光法检测两组孕妇血清PCT水平，采用散射比浊法检测CRP水平，产后取胎盘组织行组织病理学检查，根据病检结果分为绒毛膜羊膜炎组和非绒毛膜羊膜炎组。 结果 胎膜早破患者的PCT阳性率68.9%，明显高于正常孕妇组（阳性率15.6%），且差异有统计学意义（P=0.000）；CRP阳性率11.1%，PCT与CRP的阳性率比较差异有统计学意义（P=0.003），PCT反映感染的敏感度明显高于CRP，且二者的阳性率表达无相关性（P=0.080）；绒毛膜羊膜炎组PCT的阳性率（67.7%）高于非绒毛膜羊膜炎组（阳性率为32.2%），且差异有统计学意义（P0.05）。 结论 PCT可对胎膜早破孕妇并发绒毛膜羊膜炎进行早期预测并给予及时治疗，值得临床推广。 　　[关键词] 降钙素原；胎膜早破；C-反应蛋白；绒毛膜羊膜炎 　　[中图分类号] R714.433 [文献标识码] B [文章编号] 2095-0616（2015）01-162-04 　　[Abstract] Objective To discuss the clinical vaulue of PCT detection in patients with premature rupture of Membranes. Methods 180 cases of patients with premature rupture of membranes （experimental group ）and patients of normal childbirth （control group）， the serum level of PCT in two groups of pregnant women was detected through the method of electrochemical luminescence， Scattering turbidimetric method was used to detect CRP level， postpartum placental tissue was sent to histopathological examination ，according to inspection results ， patients were divided into chorioamnionitis group and non chorioamnionitis group. Results The positive rates of PCT in pregnant women with PROM（68.9%） were significantly higher than those in control group（15.6%），and there was significant difference between the two groups； The positive rates of CRP were 11.1%， and there was significant difference between the positive rates of PCT and CRP.PCT levels are seemed to be more sensitive than CRP in the diagnostic of infection and there were no relationship between the positive rates of PCT and CRP. The positive rates of PCT in pregnant women with chorioamnionitis group （67.7%） were significantly higher than those in control group （32.2%）， and there was significant difference between the two groups. Conclusion PCT has important clinical guiding significance on early prediction and treatment in pregnant women with PROM and chorioamnionitis， and it has clinical promotion signifi