BIOLOGICAL NETWORK - UB Computer Science and E.PPT

BIOLOGICAL NETWORKS Woochang Hwang BIOLOGICAL NETWORKS Introduction Biological Networks Protein-Protein Interaction Networks Signaling Metabolic Pathway Networks Expression Networks Biological Networks’ Properties Databases Discussion STM Clustering Model Introduction Bioinformatics Informatics Its carrier is a set of digital codes and a language. In its manifestation in the space-time continuum, it has utility (e.g. to decrease entropy of an open system). Bioinformatics The essence of life is information (i.e. from digital code to emerging properties of biosystems.) Bioinformatics is the study of information content of life From the particular to the universal Genome Size Proteom Size (PDB) BIOLOGICAL NETWORK Networks are found in biological systems of varying scales: 1. Evolutionary tree of life 2. Ecological networks 3. Expression networks 4. Regulatory networks - genetic control networks of organisms 5. The protein interaction network in cells 6. The metabolic network in cells … more biological networks Why Study Networks? It is increasingly recognized that complex systems cannot be described in a reductionist view. Understanding the behavior of such systems starts with understanding the topology of the corresponding network. Topological information is fundamental in constructing realistic models for the function of the network. Biological Network Model Network A linked list of interconnected nodes. Node Protein, peptide, or non-protein biomolecules. Edges Biological relationships, etc., interactions, regulations, reactions, transformations, activation, inhibitions. Biological Network Model It is usually represented by a 2-D diagram with characteristic symbols linking the protein and non-protein entities. Protein Interaction Network Proteins in a cell There are thousands of different active proteins in a cell acting as: enzymes, catalysors to chemical reactions of the metabolism components of cellular ma