复方冰硼冲洗液体外抑菌效果的评价.docVIP

复方冰硼冲洗液体外抑菌效果的评价 　　[摘要] 目的 评价纯中药制剂复方冰硼冲洗液和冰硼冲洗液对4种牙髓病原菌的体外抗菌活性。方法 采用琼脂稀释法，测定复方冰硼冲洗液和冰硼冲洗液对4种厌氧病原菌牙龈卟啉单胞菌、中间普氏菌、具核梭杆菌和粪肠球菌的最小抑菌浓度（MIC）和最小杀菌浓度（MBC）。结果 2种冲洗液对4种厌氧病原菌均有抗菌作用，复方冰硼冲洗液的抗菌性优于冰硼冲洗液。粪肠球菌的抗药能力明显强于其余3种菌株。结论 纯中药制剂复方冰硼冲洗液具有良好的抗菌性，作为根管冲洗液可能是有优势的。 　　[关键词] 复方冰硼冲洗液； 根管冲洗； 抗菌性 　　[中图分类号] R 739.86 [文献标志码] A [doi] 10.7518/hxkq.2013.04.006 　　Evaluation on antimicrobial efficacy of Fufang Bingpeng irrigant： An in vitro study Shi Yan1， Yang Jian1， Chen Hao2. （1. Dept. of Conservative Dentistry and Endodontics， Stomatology Hospital of Nanchang University， Nan-chang 330006， China； 2. Dept. of Pharmacy， The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine， Nanchang 330006， China） 　　[Abstract] Objective To evaluate the antimicrobial efficacy of Fufang Bingpeng irrigant and Bingpeng irrigant on four endodontic pathogen bacteria. Methods The agar dilution method was used to observe the antimicrobial activity of Fufang Bingpeng irrigant， Bingpeng irrigant against four selected endodontic pathogen bacteria（Porphyromonas gingi-valis， Prevotella intermedius， Fusobacterium nucleatum， Enterococcus faecalis）. Minimum inhibitory concentration and minimum bactericidal concentration was examined. Results Two irrigants had the antimicrobial activity against the anaerobic microorganisms. The antimicrobial efficacy of Fufang Bingpeng irrigant was better than that of Bingpeng irri-gant. Compared with others， Enterococcus faecalis had the strongest resistance. Conclusion Fufang Bingpeng irrigant has good antibacterial activity. As a root canal irrigant， Chinese medicine alteratives might be advantageous. 　　[Key words] Fufang Bingpeng irrigant； root canal irrigation； antimicrobial efficacy 　　根管内的细菌在牙髓和根尖周病中扮演重要的角色。根管治疗的成功取决于根管内感染的有效控制。根管冲洗是根管治疗的重要步骤，能有效去除根管内病原菌、残髓和牙本质碎屑，维持根管的清洁和非感染状态。根管冲洗液的种类很多，但都存在一定缺陷。中药具有独特的清热解毒、消肿止痛作用，且毒副作用小，作为根管冲洗液有其优势；但目前多数研究[1-2]尚停留在成品中药制剂上，其制剂的水溶液呈黄色，会对白色的牙体组织产生一定的染色作用，影响美观。本研究将白色中药——复方冰硼和冰硼按中医组方的原则进行配制，制成根管冲洗液，探索用于感染根管冲洗消毒的可行性。 　　1 材料