硝苯地平联合卡托普利治疗原发性高血压的临床效果分析.docVIP

硝苯地平联合卡托普利治疗原发性高血压的临床效果分析 　　[摘要] 目的 观察研究硝苯地平联合卡托普利治疗原发性高血压的临床效果。 方法 将入住本院心血管内科并已确诊为原发性高血压的136例患者随机分为观察组68例和对照组68例。观察组患者进行使用硝苯地平控释片和卡托普利治疗，对照组患者服用卡托普利进行治疗。系统治疗8周后，评价两组患者的临床效果。结果 观察组的总有效率为92.65%，对照组为75.00%，观察组的疗效明显优于对照组（P0.05）。观察组的舒张压和收缩压均明显低于对照组，两组差异有统计学的意义（P0.05）。 结论 硝苯地平联合卡托普利治疗原发性高血压的效果优于与单独服用卡托普利。 　　[关键词] 硝苯地平；卡托普利；原发性高血压；临床研究 　　[中图分类号] R544.1[文献标识码] A[文章编号] 1674-4721（2014）06（b）-0090-03 　　 　　Clinical effect analysis of nifedipine combining with captopril in the treatment of primary hypertension 　　WEN Xi-jing 　　Department of Internal Medicine,Worker′s Hospital of Henan Coal Construction Group Co.,Ltd.,Zhengzhou City,Zhengzhou 450009,China 　　[Abstract] Objective To observe the clinical effect of nifedipine combining with captopril in the treatment of primary hypertension. Methods One hundred and thirty-six patients who were definitely diagnosed as primary hypertension and were admitted into our department of cardiovascular medicine were randomly divided into observation group and control group.In the observation group,patients were treated by nifedipine controlled release tablet combining with captopril,while in the control group,only captopril was provided.After 8-week systemic treatment,the clinical effect was analyzed and evaluated in the two groups. Results The total effective rate in the observation group was 92.65%,much higher than that in the control group,which accounted for 75.00% (P0.05).The diastolic pressure and systolic pressure in the observation group were both lower than those in the control group with statistical differences (P0.05). Conclusion Combination of nifedipine and captopril can obtain a better effect than that only by captopril. 　　[Key words] Nifedipine;Captopril;Primary hypertension;Clinical research 　　高血压是一种以动脉舒张压和动脉收缩压持续升高为特征的常见疾病，按照发病原因可分为原发性和继发性的高血压[1]。原发性高血压的发病原因多数不明确，且病情十分复杂。近些年来，由于人们的生活水平不断提高，生活方式不断改变以及人口的不断老龄化，原发性高血压的发生率也逐年升高，严重降低影响人们的生活质量和身心健康，而且这早已成为全球化的健康问题[2]。至今，在医学临床上常用来降压的药物种类繁多，其治疗效果和不良反应都有相同之处，本研究回顾性分析2012年4