吲达帕胺联合氨氯地平治疗高血压合并冠心病患者的疗效研究.docVIP

吲达帕胺联合氨氯地平治疗高血压合并冠心病患者的疗效研究 　　[摘要] 目的 探讨吲达帕胺联合氨氯地平治疗高血压合冠心病的临床效果。 方法 选择2013年7月～2014年11月于我院确诊为高血压合并冠心病患者136例作为研究对象，分为观察组和对照组，每组68例，对照组采用硝苯地平控释片治疗，观察组采用吲达帕胺与氨氯地平联合治疗，比较两组患者的临床疗效、血压及血脂水平的变化。 结果 与对照组比较，观察组总有效率明显较高，两组差异有统计学意义（P0.05）。治疗后两组舒张压、收缩压、三酰甘油、总胆固醇水平均明显低于治疗前，观察组各指标水平下降的程度高于对照组，两组差异有统计学意义（P0.05）。 结论 吲达帕胺和氨氯地平联合用药治疗高血压合并冠心病能够起到协同增效的作用，可有效控制患者的血压水平，改善血脂情况，有较高的安全性。 　　[关键词] 高血压；冠心病；吲达帕胺；氨氯地平 　　[中图分类号] R544.1 [文献标识码] B [文章编号] 2095-0616（2015）11-69-03 　　[Abstract] Objective To investigate the clinical results of hypertension combined coronary heart disease treated with indapanmide and amlodipine. Methods 136 cases with hypertension and coronary heart disease were selected from July 2013 to November 2014 in our hospital as research subjects， they were divided into the observation group and the control group， 68 cases in each group， the control group used nifedipine GITS treatment， the observation group used indapamide combination therapy with amlodipine， the clinical efficacy and the change of blood pressure and blood lipid levels of the two groups were compared. Results The total efficiency of the observation group was significantly higher than the control group， the difference was statistically significant （P0.05）. After treatment， diastolic， systolic blood pressure， triglycerides， total cholesterol levels of two groups were significantly lower than before treatment， the degree of decline in the index level of the observation group was higher than the control group， the difference was statistically significant （P0.05）. Conclusion Indapamide and amlodipine combination therapy of hypertension and coronary heart disease can play a synergistic effect， can effectively control blood pressure levels in patients， improve lipid profile， with high security. 　　[Key words] Hypertension； Coronary heart disease； Indapamide； Amlodipine 　　高血压是临床常见的一种慢性心血管疾病，是心脑血管病最主要的危险因素，有较高的发病率，确诊后需要长期治疗[1]。高血压长期发展会导致冠状动脉粥样硬化，使血管腔狭窄或阻塞，从而引起心肌缺血缺氧或坏死，形成冠状动脉性心脏病，即为冠心病[2]。近年来，随着我国经济的发展、生活方式的改变及