翼状胬肉切除联合自体结膜瓣移植术后泪膜稳定性研究.docVIP

翼状胬肉切除联合自体结膜瓣移植术后泪膜稳定性研究 　　摘要：目的 探讨翼状胬肉切除联合自体结膜瓣膜移植术对泪膜稳定性的影响。方法 研究共纳入86例单眼翼状胬肉患者，就诊时间2011年7月～2014年4月，所有患者均行翼状胬肉切除联合自体结膜瓣移植术。分别于术前1wk；术后2wk；1mo，3mo行双眼泪膜功能检查，包括泪液分泌试验（Schirmer I test，SIt）、泪膜破裂时间（break-up time， BUT）、角膜荧光色染色评分（corneal fluoresescein staining，CFS）。设手术眼为研究组， 对侧眼为对照组。结果 Schirmer I test：研究组与对照组相比，术前及术后各个阶段两组之间均无显著性差异（P0.05）；BUT：两组术前1wk与术后2wk，1mo比较均有显著性差异（P0.05）；CFS：两组比较术前及术后各个时间点比较均有显著性差异（均P0.05）。结论 翼状胬肉患者眼表存在明显的泪膜稳定性异常；翼状胬肉切除联合自体结膜瓣移植术可以显著改善术后泪膜功能。 　　关键词：翼状胬肉；自体结膜瓣；移植；泪膜稳定性；泪液 　　Clinical Research of Tear Film Stability after Pterygium Excision with Conjunctival Autograft Transplantation 　　LI Dan-dan， ZHANG Wan-hong，TIAN Qiang 　　（Tianjin TEDA Hospital，Tianjin 300457，China） 　　Abstract：Objective To discuss the influence to tear film function of patients with pterygium excision combined with conjunctival autograft transplantation. Methods Totally 86 patients underwent pterygium excision with conjunctival autograft transplantation from July 2011 to April 2014 were entered in the study. The Schirmer I test （SIt），The tear break-up time （BUT）， and corneal fluoresescein staining（CFS）were done in the patients before and after surgries. The examnation times were 1wk before and 2wk， 1， 3mo after surgery. Operation eyes were taken on studied group， the fellow eyes as control group. Results No obvious difference was detected in the results of SIt at any time in the two groups（P0.05）. The results of BUT was significantly different in the eyes between the two groups 1week before，and two weeks and 1 month after surgery（P0.05）. There were significantly difference in the results of CFS between two groups at any time in the study （P0.05）. Conclusion Tear film stability was broken in the eyes with pterygium. Pterygium excision combined with conjunctival autograft transplantation can obviously restore the tear film function into normal state. 　　Key words：Pterygium；Conjunctival autograft；Transplantation；Tear film stability；Tear 　　翼状胬肉是临床常见的眼科疾病，但是直到今天关于翼状胬肉形成确切病因没有形成