好论文是怎样锻造出来的__培训课件.pptVIP

所以，我们团队研究的核心问题就是病毒是怎样逃匿宿主的免疫反应，尤其是先天免疫。 * 所以，我们团队研究的核心问题就是病毒是怎样逃匿宿主的免疫反应，尤其是先天免疫。 * 所以，我们团队研究的核心问题就是病毒是怎样逃匿宿主的免疫反应，尤其是先天免疫。 * 所以，我们团队研究的核心问题就是病毒是怎样逃匿宿主的免疫反应，尤其是先天免疫。 * 所以，我们团队研究的核心问题就是病毒是怎样逃匿宿主的免疫反应，尤其是先天免疫。 * 所以，我们团队研究的核心问题就是病毒是怎样逃匿宿主的免疫反应，尤其是先天免疫。 * We also attempted to knockdown the endogenous KIF3A expression in BCBL-1 cells. A lentivirus based approach was employed to generate cells harboring the KIF3A shRNA sequences integrated into the host cell genome. Stable knockdown of KIF3A expression manifested as a highly significant reduction in viral egress. We also included a set of shRNAs against KHC (kinesin-1) in the studies to look into the role of KHC in KSHV transport. KHC has been implicated in transportation of HSV-1. KHC shRNA had little effect on KSHV virion production. However,t knockdown of KHC displayed little effects on KSHV-1 egress but block HSV-1 production completely , exemplified the specificity of kinesin-2 in KSHV transport and KHC in HSV-1 movement on microtubules. KSHV is a relatively new member of human herpesviruses. It is associated with Kaposi’s sarcoma as well as a number of lymph-proliferative diseases such as primary effusion lymphoma and multicentric Castleman’s disease. Kaposis sarcoma (KS) is a vascular tumor. It used to be a rare disease, but in AIDS epidemic, it became a major AIDS-associated malignancies. Our laboratory has been studying the lytic life cycle of KSHV for many years. Recently, we realized that although a lot of studies have been done with gene regulation, DNA replication, but little is known about KSHV virion and its assembly and release. Therefore, we decided to do something on it. This slide depicts the structure of a KSHV virion. A linear double-stranded viral genomic DNA is enclosed within a nucleoprotein core called capsid. The capsid is surrounded by an envelope with glycoprotein spikes on the surface. Located between is an electron dense material called tegument. This proteomics analysis led to the id