正常人群动脉弹性功能影响因素的研究.doc

正常人群动脉弹性功能影响因素的研究 陈小明，林金秀，苏津自，王华军，彭 峰，曾开淇，吴可贵 （福建医科大学附属第一医院心血管内科，福建省高血压研究所，福建 福州 350005） Influencing Factors of Artery Elastic Function on Healthy People CHEN Xiao-ming, LIN Jin-xiu, SU Jin-zi, WANG Hua-jun, PENG Feng, ZENG Kai-qi (The first affiliated hospital of Fujian medical university, the hypertension institute of Fujian, Fuzhou, 350005, China) Abstract Objective To investigate the reproducibility and influencing factors of the large and small artery elasticity indices C1 and C2 in healthy subjects. Methods Three hundred and twenty healthy subjects were enrolled and categoried into 4 groups (15~30y, 31~45y, 46~60y, 60~80y), each group comprise 80 subjects, male/female ratio=1. C1 and C2 were detected 3 times by HDI CV Profilor DO-2020 and the mean, C1 and C2 examined 7~28 days later. All subjects discontinued all medications 30days before the examination. Results (1) Mean C1 of healthy people is 15.39±4.37(ml/mmHg×10), C2 is 6.35±3.07(ml/mmHg×100), and C1 and C2 in male are higher than in female, P 0.05 (2) the reliability and reproducibility of C1 and C2 are satisfied, and the differences of the twice examinations are not significant, P0.05. (3) C1 and C2 decrease gradually but significantly with age P0.05. (4) C1 correlates with age, pulse pressure, mean pressure, systolic pressure, heart rate and diastolic pressure, P0.01;C2 correlates with age, mean pressure, diastolic pressure, systolic pressure, heart rate and pulse pressure, P0.01;While no correlation between BMI and C1 and C2, P0.05. Conclusion (1) the reproducibility of C1 and C2 measurements are satisfied, C2 reflects the early change of elastic function in small blood vessel. (2) the elastic function in large and small artery decrease gradually with age. (3) Both C1 and C2 are affected by age, C1 is predominately affected by systolic pressure, and C2 by diastolic pressure. Key works: artery elastic function; age; blood pressure 摘要： 目的 研究正常人群动脉弹性功能指数C1、C2在短期内重复的可靠性、稳定性及探讨C1、C2的影响因素。方法 正常人群3