近红外光谱技术对新生儿缺氧性脑损伤的评价探讨.docVIP

近红外光谱技术对新生儿缺氧性脑损伤的评价探讨( 谢小强，蒋丽红，苏国云 深圳市光明新区公明人民医院新生儿科 【摘　要】 目的：探讨近红外光谱技术对新生儿缺氧缺血性脑损伤和脑组织灌注的评价，为临床评价脑损伤提供客观依据。方法：应用近红外光谱技术和脉搏血氧饱和度监测技术，分别测定脑损伤患儿生后30分钟及生后72小时脑组织血氧饱和度与脉搏血氧饱和度，并与同时间点测定的正常对照组进行比较，以了解脑组织血氧饱和度测定与脉搏血氧饱和度测定在新生儿缺氧缺血性脑损伤早期评价方面的应用。结果：生后30分钟的缺氧缺血性脑病（hypoxic ischemic encephalopathy, HIE）新生儿脑组织氧饱和度为51.6%±4.3% ,低于正常对照组的59.8%±4.6%，差异有显著性( P 0. 01) ，生后72小时HIE组新生儿脑组织氧饱和度为53.4%±4.7% ,低于正常对照组的60.1%±4.4%，两者之间比较差异有显著性( P 0. 01) 。结论：在新生儿缺氧缺血性脑病时，脑组织氧饱和度测定比脉搏血氧饱和度测定更能客观的评价脑组织的损伤。 【关键词】 近红外光谱；脑组织氧饱和度；新生儿缺氧缺血性脑病 The evaluation of near-infrared spectroscopy used in neonatal hypoxic brain injury ? Xie Xiaoqiang, Jiang Lihong, Su Guoyun Department of Neonatology, Gongming Peoples Hospital, Guangming District, Shenzhen 【Abstract】 Objective: To explore the near-infrared spectroscopy on neonatal hypoxic-ischemic brain injury and brain tissue perfusion evaluation and to provide objective basis for clinical evaluation of brain injury. Methods: using near-infrared spectroscopy and pulse oxygen saturation monitoring technology, brain tissue oxygen saturation and pulse oxygen saturation was measured on children with brain injury at 30 minutes after birth, and 72 hours after birth, compared with the same measurement on the normal control group，the brain tissue oxygen saturation and pulse oxygen saturation was measured for the early evaluation of applications in neonatal hypoxic-ischemic brain injury. Results: 30 minutes after birth, hypoxic-ischemic encephalopathy (HIE) neonatal brain tissue oxygen saturation (51.6% ± 4.3%), lower than the control group (59.8% ± 4.6%), the difference was significant (p0. 01), while 72 hours after birth, HIE brain tissue oxygen saturation (53.4% ± 4.7%), lower than the control group (60.1% ± 4.4%), the difference between the two significant (p0. 01). Conclusion: In neonates with hypoxic ischemic encephalopathy, brain tissue oxygen saturation has more objective assessment than pulse oxygen saturation in the determination of brain tissue damage. 【Key