依达拉奉对二尖瓣置换术患者的脑保护作用.docVIP

依达拉奉对二尖瓣置换术患者的脑保护作用 　　[摘要] 目的 观察依达拉奉对体外循环（CPB）下行二尖瓣置换术患者的脑保护作用，并探讨其机制。 方法 选择选择2010年1月～2013年8月于首都医科大学石景山教学医院拟行二尖瓣置换手术患者36例，随机分为依达拉奉组和对照组，每组各18例。依达拉奉组将依达拉奉30 mg加入100 mL生理盐水中于体外循环前30 min静脉滴注；对照组输入等量生理盐水。分别于麻醉后用药前（T1）、CPB结束后5 min（T2）、4 h（T3）、24 h（T4）、48 h（T5）、72 h（T6）检测血清中的神经元特异性烯醇化酶（NSE）、神经组织蛋白（S-100 ββ）水平。观察并比较两组术后神经系统并发症的发生情况。 结果 T1时点两组NSE水平比较，差异无统计学意义（P 0.05）。依达拉奉组NSE水平在T2时点低于对照组，差异有统计学意义（P 0.05）；T2、T3、T4时点依达拉奉组S-100 ββ水平均低于对照组，差异有统计学意义（P 0.05）。 结论 依达拉奉可减少神经组织蛋白、神经元特异性烯醇化酶在围体外循环期的表达，对心脏瓣膜手术患者有一定脑保护作用。 　　[关键词] 依达拉奉；心肺转流；自由基；脑保护 　　[中图分类号] R614 [文献标识码] A [文章编号] 1673-7210（2014）08（a）-0070-04 　　Cerebral protective effect of Edaravone in patients underwent mitral valve replacement 　　ZHAO Libo ZHAO Qiuhua 　　Department of Anesthesiology， Shijingshan Teaching Hospital of Capital Medical University Shijingshan Hospital of Beijing City， Beijing 100043， China 　　[Abstract] Objective To observe the cerebral protective effect of Edaravone in patients underwent mitral valve replacement， and discuss its mechanism. Methods 36 cases of patients underwent mitral valve replacement were selected， and randomly divided into the Edaravone group and the control group， with 18 cases in each group. Patients in the Edaravone group were given 30 mg Edaravone added 100 mL saline for intravenous drip 30 min before cardiopulmonary bypass， while patients in the control group were given the same amount of saline. The NSE and S-100 ββ levels were detected before drug given （T1）， 5 min （T2）， 4 h （T3）， 24 h （T4）， 48 h （T5）， 72 h （T6） after cardiopulmonary bypass. The neurological complications were recorded and compared. Results At T1， there was no significant difference in NSE level between the two groups （P 0.05）. At T2， the NSE level in the Edaravone group was lower than that in the control group， the difference was statistically significant （P 0.05）. At T2， T3， T4， the S-100 ββ levels in the Edaravone group were lower than the control group， the differences were statistically signific