呼吸机联合阿托品与氯解磷定治疗重度有机磷农药中毒的临床研究.docVIP

呼吸机联合阿托品与氯解磷定治疗重度有机磷农药中毒的临床研究 　　[摘要] 目的 观察呼吸机联合不同剂量阿托品和氯解磷定治疗濒死重度有机磷农药中毒的临床效果。 方法 117例濒死重度有机磷农药中毒患者，根据是否用使用呼吸机分为呼吸机联合阿托品氯解磷定组（治疗组），仅使用阿托品氯解磷定、未用呼吸机组（对照组）。治疗组根据入院后最大阿托品用量分为两亚组，适量组：最大用量≤100 mg/h；大剂量组：最大用量100 mg/h。 结果 治疗组痊愈率高于对照组，差异有统计学意义（P0.05）。 结论 抢救濒死重度有机磷农药中毒，应在阿托品联合复能剂的基础上应用机械通气，机械通气要及时，阿托品应该足量、个体化使用，尽量避免大剂量应用，用药过程中严密观察患者的反应。 　　[关键词] 呼吸机；阿托品；氯解磷定；有机磷农药；重度中毒；临床研究 　　[中图分类号] R595.4[文献标识码] A[文章编号] 1674-4721（2014）06（a）-0027-03 　　 　　Clinical research of respirator combined with atropine and pralidoxime chloride treating severe organophosphorus pesticide poisoning 　　TAN Zhao-gen XIONG Man-ying WU Mei-zhen 　　Department of Critical Care Medicine,Fengcheng People′s Hospital in Jiangxi Province,Fengcheng 331100,China 　　[Abstract] Objective To observe the clinical effect of respirator combined with atropine and pralidoxime chloride treating severe organophosphorus pesticide poisoning. Methods 117 cases of patients with severe organophosphorus pesticide poisoning were selected and divided into two groups,the treatment group (respirator combined with atropine and pralidoxime chloride group) and the control group (only using atropine and pralidoxime chloride without using respirator group).And according to the maximal dosage of atropine,the treatment group was divided into two subgroups.For the appropriate amount group,the maximal usage was less than or equal to 100 mg/h,and for the large dosage group,the maximal usage was greater than 100 mg/h. Results The recovery rate of the treatment group and control group had significant difference (P0.05). Conclusion Rescuing the patients with severe organophosphorus pesticide poisoning should use mechanical ventilation based on atropine combined with pralidoxime chloride.Mechanical ventilation should be timely.And there is enough atropine,and it is used individually.And large-dosage application should be avoided.The reaction of patients should be observed in the medication process. 　　[Key words] Respirator;Atropine;Pralidoxi