03-BLAST生物信息学国外教程2010版课件.pptVIP

* * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * BLAT Fig. 5.20 Page 167 LAGAN Fig. 5.21 Page 168 SSAHA Outline of today’s lecture BLAST Practical use Algorithm Strategies Finding distantly related proteins: PSI-BLAST Hidden Markov models BLAST-like tools for genomic DNA PatternHunter Megablast BLAT, BLASTZ Where we are in the course --We started with “access to information” (Chapter 2) --We next covered pairwise alignment (Chapter 3), then BLAST in which one sequence is compared to a database (Chapters 4, 5) --Ne