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Global Initiative for Chronic Obstructive Lung Disease GOLD Executive Committee1997 R. Pauwels, Belgium – Chair S. Buist, US C. Jenkins, Australia P. Calverley, UK N. Khaltaev, Switzerland B. Celli, US C. Lenfant, US Y. Fukuchi, Japan J. Luna, Guatemala S. Hurd, US W. MacNee, UK L. Grouse, US N. Zhong, China Executive CommitteeChair: Leonardo M. Fabbri, MD Executive CommitteeChair: Sonia Buist, MDCo-Chair: to be nominated GOLD REPORT – Chapter 1Page 6, right column, para 2 ORIGINAL TEXT COPD is a disease state characterized by airflow limitation that is not fully reversible. The airflow limitation is usually both progressive and associated with an abnormal inflammatory response of the lungs to noxious particles or gases. REVISION COPD is a preventable and treatable disease characterized by airflow limitation that is not fully reversible. The airflow limitation is usually both progressive and associated with an abnormal inflammatory response of the lungs to noxious particles or gases, particularly to cigarette smoking. COPD, and particularly severe and very severe COPD is a multi-component disease characterized by a range of pathological changes, including some significant extra-pulmonary effects (eg cachexia, osteoporosis). GOLD REPORT – Chapter 1Page 7, left column, last line, Title of figure 1.2 ORIGINAL TEXT CLASSIFICATION OF SEVERITY FEV1/FVC 70% Rationale for post-bronchodilator FEV1 Use of reversibility testing REVISION SPIROMETRIC CLASSIFICATION OF SEVERITY The fixed limit of post-bronchodilator FEV1/FVC 70% is indicated only for screening purposes, as it may overestimate airflow limitation, particularly in the elderly Spirometric values are reported as post-bronchodilator to minimize the variability due to reversibility of airflow limitation While reduced post-bronchodilator FEV1/FVC ratio and FEV1 are recommended for the diagnosis