Severe Acute Respiratory Syndrome gxu严重急性呼吸综合征西大.cn.pptVIP

Severe Acute Respiratory Syndrome (SARS)David S. Stephens MD Age of Aquarius “One can think of the middle of the 20th century as one of the most important social revolutions in history- the elimination of the infectious disease as a significant factor in social life” Sir Frank MacFarland Burnet 1962, 1960 Nobel Laureate for Medicine “Infectious Diseases will be eliminated as a major threat to human health” US Surgeon General 1967 Microbial Evolution Ignored historical and ecological data that emergence and reemergence of infections have been common place in nature throughout evolution Plague - Hepatitis C - Diphtheria Anthrax - Dengue - Helicobacter HIV - EBOLA - Hantavirus Lyme - Legionnaire’s Disease - West Nile Factors in Emergence and Reemergence of Infections Microbial Mutation and Horizontal Recombination Rapid generation time and high copy number 3.8 billion years of microbial evolution and diversity The vast majority of microorganisms remain uncultured and unknown Urbanization and Land Use Globalization and Population Growth Environmental and Social Changes Severe Acute Respiratory Syndrome (SARS) Emergence Clinical Features Pathogenesis Transmission and Infection Control Treatment The Future Severe Acute Respiratory Syndrome (SARS) Atypical pneumonia/ARDS caused by a newly identified coronavirus First recognized in Hanoi, Vietnam on February 26th, 2003 by Dr Carlo Urbani. As of June 6th, WHO had received reports of 8404 cases of probable SARS from China, Hong Kong Special Administrative Region of China, Canada, Vietnam, Singapore, Thailand, United States and 22 other countries. Thus far 779 people have died and 5937 have recovered (11.6 % mortality). PATIENT A Physician from Guangdong province China Onset of symptoms on February 15, 2003 Visit to relatives in Hong Kong 21 February Stayed in Hotel M in Room 911 Admitted to Hong Kong Hospital 22 February and died the next day 12 patients