参芪膏对气虚质亚临床甲状腺功能减退患者临床疗效初步评价.docVIP

参芪膏对气虚质亚临床甲状腺功能减退患者临床疗效初步评价 　　摘要：目的 观察参芪膏对气虚质亚临床甲状腺功能减退患者的临床疗效。方法 将60例气虚质亚临床甲状腺功能减退患者随机分为2组，对照组口服优甲乐，治疗组口服中药膏方参芪膏，疗程6个月，观察2组干预前后颈动脉内膜中层厚度（CIMT）、甲状腺功能指标[游离三碘甲腺原氨酸（FT3）、游离甲状腺素（FT4）、促甲状腺激素（TSH）、甲状腺球蛋白抗体（TG-Ab）、甲状腺过氧化酶抗体（TPO-Ab）]及中医证候积分变化。结果 治疗组在改善中医证候积分方面明显优于对照组（P0.01），在改善颈动脉内膜中层厚度方面优于对照组（P0.05），在降低血清TG-Ab、TPO-Ab水平方面优于对照组（P0.01）。结论 参芪膏对气虚质亚临床甲状腺功能减退患者临床疗效可靠。 　　关键词：参芪膏；气虚质；亚临床甲状腺功能减退 　　DOI：10.3969/j.issn.1005-5304.2016.07.007 　　中图分类号：R259.812 文献标识码：A 文章编号：1005-5304（2016）07-0026-04 　　Preliminary Evaluation of Clinical Efficacy of Shenqi Unguent on Sub-clinical Hypothyroidism Patients with Qi-deficiency Constitution TENG Tao （The Second Affiliated Hospital of Shangdao University of Chinese Medicine， Jinan 250001， China） 　　Abstract： Objective To observe the clinical efficacy of Shenqi Unguent on sub-clinical hypothyroidism patients with qi-deficiency constitution. Methods A total of 60 patients were randomly divided into treatment group and control group. The treatment group took the traditional Chinese medicine of Shenqi Unguent， while the control group took euthyrox orally for 6 months. Changes of carotid intima-media thickness （CIMT）， thyroid function （FT3， FT4， TSH， TG-Ab， TPO-Ab）， and TCM syndrome integral before and after treatment of the two groups were observed. Results After treatment， the TCM syndrome integrals of the treatment group were significantly improved， compared with the control group （P0.01）. Similarly， CIMT of the treatment group were obviously increased， compared with the control group （P0.05）. Meanwhile， levels of serum TG-Ab and TPO-Ab were distinctly reduced than that of the control group （P0.01）. Conclusion Shenqi Unguent has marked clinical efficacy on sub-clinical hypothyroidism patients with qi-deficiency constitution. 　　Key words： Shenqi Unguent； qi-deficiency constitution； sub-clinical hypothyroidism 　　亚临床甲状腺功能减退（以下简称“甲减”）是指血清促甲状腺激素（TSH）升高（4.5 mIU/L）而血浆游离三碘甲腺原氨酸（FT3）、血清游离甲状腺素（FT4）处于正常范围，且患者无明显甲减症状和体征的一类疾病。近年来，亚临床甲减发病率逐年上升，美国成人亚临床甲