新生儿降钙素原、白细胞计数、超敏C―反应蛋白与应激状态的相关性.docVIP

新生儿降钙素原、白细胞计数、超敏C―反应蛋白与应激状态的相关性 　　[摘要] 目的 新生儿降钙素原（PCT） 、白细胞计数（WBC）、超敏C-反应蛋白（hsCRP）与应激状态关系的探讨。方法 将2013年11月―2015年8月，出生3 d转入该院儿科新生儿监护室未使用抗菌素的足月新生儿391例，分为应激组（包括呕吐和窒息）、非应激组和对照组（健康的新生儿30例），于生后3 d抽股静脉血，用电化学发光法查血清降钙素原、白细胞计数、超敏C-反应蛋白（hsCRP），用T检验统计应激组（包括呕吐与窒息）与非应激组及对照组各感染指标的差异。 结果 应激组与非应激组的WBC、PCT 、hsCRP指标差异无统计学意义（P0.05）；应激组与健康组比较，WBC、PCT指标差异有统计学意义（PCT：t=2.918， P0.05）。 结论 应激状态可引起WBC、PCT 异常增高，对hsCRP影响不明显，多指标综合判断，更能反映患儿的真实状态。 　　[关键词] 新生儿；降钙素原；抗菌素；感染指标；超敏C-反应蛋白；应激状态 　　[中图分类号] R722.1 [文献标识码] A [文章编号] 1674-0742（2016）04（c）-0059-02 　　[Abstract] Objective To analyze the correlation between neonatal procalcitonin， white blood cell count， high sensitive C-reactive protein and stress state. Methods 391 cases of full-term and antibiotics-unused neonates transferred to the neonate intensive care unit of our hospital at 3d after birth from November 2013 to August 2015 were divided into the stress group （including vomiting and asphyxia）， non-stress group and control group （30 cases of healthy neonates）， the femoral vein blood was drawn at 3d after birth， the serum procalcitonin， white blood cell count and high sensitive C-reactive protein were examined by the electrochemiluminescence， and the differences in the various infectious indexes between the stress group （including vomiting and asphyxia）， non-stress group and the control group were counted by T-test. Results The differences in the WBC， PCT and hsCRP indexes between the stress group and the non-stress group were not statistically significant（P0.05）， the WBC and PCT indexes had statistical significance between the stress group and the healthy group（PCT： t=2.918， P0.05）. Conclusion The stress state can cause the elevation of WBC and PCT abnormalities and has no obvious effect on hsCRP， and the multiple-index comprehensive judge can better reflect the true state of children. 　　[Key words] Neonate； Procalcitonin； Antibiotics； Infection index； High Sensitive C-reactive Protein； Stress State 　　降钙素原能早期反映细菌感染、真菌感染及寄生虫感染的检测手段。由于新生儿感