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Qualitative and quantitative composition of essential oils A literature-based database on contact allergens used for safety assessment.pdf

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Qualitative and quantitative composition of essential oils A literature-based database on contact allergens used for safety assessment.pdf

Regulatory Toxicology and Pharmacology 80 (2016) 226e232 Contents lists available at ScienceDirect Regulatory Toxicology and Pharmacology journal homepage: /locate/yrtph Qualitative and quantitative composition of essential oils: A literaturebased database on contact allergens used for safety assessment N. Dornic*, A.S. Ficheux, A.C. Roudot Laboratoire d’Evaluation du Risque Chimique pour le Consommateur (LERCCo), Universite Europeenne de Bretagne, Universite de Bretagne Occidentale (UEB-UBO), UFR Sciences et Techniques, 6 Av. Victor Le Gorgeu, CS93837 29238, Brest Cedex 3, France article info Article history: Received 5 May 2016 Received in revised form 18 June 2016 Accepted 21 June 2016 Available online 29 June 2016 Keywords: Aromatherapy Exposure assessment Database Contact sensitization Dermal exposure abstract The risks related to the use of essential oils are dif?cult to ascertain at present, due in part to the large number of different oils available on the market, making it dif?cult for the risk assessor. Essential oils may contain skin allergens in signi?cant amounts, and could thus pose a risk to the consumer. The aim of our study was to collect as much qualitative and quantitative data as possible on allergens present in essential oils. 11 types of essential oils, with 25 respective subspecies, were taken into account based on a previous survey. Based on the literature, 517 dosages were recorded from 112 publications, providing precious information for probabilistic exposure assessment purposes. 22 substances recognized as established allergens were found in the essential oils we included. Of these, 11 are also found in cosmetics as fragrance components. These results are of major importance regarding co-exposure to fragrance allergens. Moreover, this could lead to regulatory measures for essential oils in the future, as it is the case for cosmetic products, in order to better protect consumers against skin allergy. ? 2016 Elsevier Inc. All rights rese