The impact of lens care solutions on corneal epithelial changes during daily silicone hydrogel contact lens wear as measured by in vivo confocal microscopy.pdfVIP

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The impact of lens care solutions on corneal epithelial changes during daily silicone hydrogel contact lens wear as measured by in vivo confocal microscopy.pdf

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The impact of lens care solutions on corneal epithelial changes during daily silicone hydrogel contact lens wear as measured by in vivo confocal microscopy.pdf

Contact Lens and Anterior Eye 40 (2017) 33–41 Contents lists available at ScienceDirect Contact Lens and Anterior Eye journal homepage: /locate/clae The impact of lens care solutions on corneal epithelial changes during daily silicone hydrogel contact lens wear as measured by in vivo confocal microscopy Xiaolin Zhanga, Christine Marchettia, Jessica Leea, Yan Suna, Sara Debanneb, Ying Jiangb, Jami Kernc, Mark Harroda, Beth Ann Benetza, Eric Pearlmana,d, Loretta Szczotka-Flynna,* a Department of Ophthalmology Visual Sciences and University Hospitals Eye Institute, University Hospitals Case Medical Center, Cleveland, OH, United States b Department of Epidemiology Biostatistics, Case Western Reserve University, Cleveland, OH, United States c Alcon Research, Fort Worth, TX, United States d Department of Ophthalmology, University of California, Irvine, United States ARTICLE INFO Article history: Received 3 March 2016 Received in revised form 9 November 2016 Accepted 11 November 2016 Keywords: Confocal microscopy Silicone hydrogel contact lens Hyper-re?ective corneal epithelial cells ABSTRACT Purpose: To assess corneal epithelial microstructure via confocal microscopy and determine if cellular changes are associated with lens care solutions during daily wear of silicone hydrogel contact lenses. Methods: Corneal in vivo confocal microscopy with the Nidek ConfoScan4 was performed at baseline and after 5 months of lotra?lcon A daily contact lens wear. Enrolled participants were randomized to use either a polyhexamethylene biguanide (PHMB) preserved multipurpose care solution (MPS) or a peroxide based solution system. Lens and storage case bioburden were assessed with aerobic culture methods. Univariate and multivariable analyses were done to evaluate the association between solution use, or solution-related clinical covariates, and morphologic differences (hyper-re?ectivity) in the super?cial epithelial cells and epithelial basal cell density. Results: Data on 139 participa