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The interface between microbiology and structural biology as viewed by nuclear magnetic resonance.pdf
Res. Microbiol. 152 (2001) 697–705 ? 2001 éditions scienti?ques et médicales Elsevier SAS. All rights reserved S0923-2508(01)01250-5/REV
Mini-review The interface between microbiology and structural biology as viewed
by nuclear magnetic resonance
Muriel Delepierre?, Anne Lecroisey
Unité de RMN des Biomolécules, URA CNRS 2185, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris cedex 15, France Received 18 February 2001; accepted 9 April 2001
Abstract – Nuclear magnetic resonance (NMR) spectroscopy is one of two principal experimental techniques used in structural biology. It can be used to determine structures at atomic resolution and to investigate the dynamics of macromolecules and intermolecular interactions. We aim to give an overview of the use of modern high resolution NMR methodology in microbiology. ? 2001 éditions scienti?ques et médicales Elsevier SAS
NMR / structural biology / methodology, microbiological
1. Introduction
2. NMR methodology
Nuclear magnetic resonance (NMR) and X-ray crystallography are the two most powerful tools available for structure determination and have been extensively used to obtain structural information on biological molecules. The limitation of X-ray crystallography lies in the necessity to obtain crystals. NMR is limited by the size of the molecule and the low sensitivity of the method. Thus, these two techniques are complementary. NMR is particularly powerful for determining the structure of small molecules, for obtaining information on the dynamics of macromolecules over a wide time scale range and for studying molecular interactions. Thus, it is not surprising that it is widely used in microbiology. Indeed, NMR can be combined with isotope labelling for noninvasive analytical and quantitative analysis of metabolism, in a range of microorganisms. It has long been a critical tool for the identi?cation of compounds and for measuring concentrations and ?uxes both in vitro and in vivo.
Firstly, we will give a brief summary for scien
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