糖尿病小鼠组织和血液的扫描量热学研究.pdfVIP

糖尿病小鼠组织和血液的扫描量热学研究 曹摩事51 ，饶伟 1，高兴 2，周东滞 S，剌静 1，2 1.中国科学院理化技术研究所，北京 100190 2. 清华大学医学院生物医学工程系，北京 100084 3. 河北医科大学内科教研室，石家庄 05以)17 捎襄 以糖尿病小鼠和正常对照小鼠为实验对象，按标准试验程序取其肺、肝和肾脏组织，同时摄取两组小鼠的血液，使用差示扫描 最热法 (DSC) 泯IJ最样品在南混 (37呻65t)和低温 (20呻-50t)条件下的扫描黯热闹线，对比分析糖尿病小鼠和iE常小鼠相应组织的热 学性质。结果袭明，正常小鼠肺和肝脏组织的高温 ~t热及血液的低温相变潜热大于糖尿病小鼠，而糖尿病小鼠肾脏组织的商温比热显 著大于正常小鼠，这些童在异可望引申出新型的糖尿病检测分析与F段。 ~.诩 糖尿病;差示扫描量热法;比热;相变潜热 中团分类骨 肉361 X献标识码 A 文，依编唔 1000-7857(2008)19叩0069-04 Scanning Calorimetric Study on Tissue and Blood Samples of Diabetic Mice ZENG Yanzhang 1 , RAO WeiI, GAO Xin矿， ZHOU Donghao 3 , LIU Jing l. 2 1. Technic a1 /nstìlute 0/ Physics and Chemistry, Chinese Acc山my o/Sciences, 8eijing /00190, China 2. Department 0/8iomedical En，伊时ering， School 0/ Medicine , Tsinghua University, 8eijing /00084, China 3. lnternal Medicine Teaching Group, Hebei Medical University, Shijiazhuang 05001 又 China Abstract Dial川ic mic暗 and nonnal control mice were chosen for experiment. Following a standard test procedur咽， the lung, liver, and kidney tissues we陀 extracted from mice of two groups and made into samples to be measured. Meanwhile, blood samples were also extracted for a comparative evaluation. 5canning calorimetric curves of the samples were mea~ured at high tem肘rature (37 -65 C) and low temperature (20--50C) ranges with Differential Scanning calorimetry (DSC).叽1日rmal properti创 of samples of the two groups were analyzed and compa陀d. 切le results show that the lung and liver tiS8U创 of nonnal mice have higher specific heat 出an those of 收稿日期: 2008-0弘30 the diabetic ones in the high temperalure range, but the sp剧:ific heat of normal kidney lissue is evidently lower than that of lhe diabelic samples. In addition, the latent heat of nonnal group blood in low temperature range was also found higher than thal of diab创ic mice blood. 5uch differences are expected 10 be used in developing certain new technical stralegy for the detennination of diabetes mellilus. Keywords diahetes mellitus; differential s