StudyontheEffectsofCoupletMedicineBaibu-Ziwanwith.pdfVIP

Pharmacy Information 药物资讯, 2017, 6(1), 6-11 Published Online February 2017 in Hans. /journal/pi /10.12677/pi.2017.61002 文章引用: 姜登钊, 李辉敏, 刘可越. 不同配比组方的百部–紫菀药对咳嗽变异性哮喘大鼠 Th1/Th2 及 Th17/Treg 细 胞因子平衡影响[J]. 药物资讯, 2017, 6(1): 6-11. /10.12677/pi.2017.61002 Study on the Effects of Couplet Medicine Baibu-Ziwan with Different Proportions on Cytokines Level of Type Th1/Th2 and Th17/Treg in Cough Variant Asthma Rats Dengzhao Jiang1, Huimin Li2, Keyue Liu1 1Key Laboratory of Jiangxi University for the Systems Biology Clinical Application, School of Pharmacy and Life Sciences, Jiujiang University, Jiujiang Jiangxi 2School of Basic Medical Science, Jiujiang University, Jiujiang Jiangxi Received: Jan. 20th, 2017; accepted: Feb. 2nd, 2016; published: Feb. 7th, 2017 Abstract Objective: To study the antiasthma mechanism of couplet medicine Baibu-Ziwan and investigate the pharmacodynamic effects on the proportion compatibility. Method: Cough variant asthma (CVA) rats were established and orally administrated by the extractions of Baibu-Ziwan with dif- ferent compatibility. The IL-4, INF-γ, IL-17 and IL-10 levels in bronchoalveolar lavage fluid (BALF) were determined by Elisa method and the numbers of inflammatory cells in BALF changes in lung were measured, respectively. The differences were tested among the groups by SPSS 19.0 software. Results: The levels of Thl/Th2 and Th17/Treg were both corrected after administration of the ex- tractions of Baibu-Ziwan with inflammatory cells (eosinophil, lymphocytes and neutrophil) de- creased in CVA group (p 0.05). Conclusion: The antiasthma mechanism of couplet medicine Bai- bu-Ziwan on CVA rats may be related to the regulating imbalance of Thl/Th2 and Th17/Treg and the decreased infiltration of inflammatory cells, and the proportion compatibility had some influ- ences on its pharmacodynamic effects. Keywords Couplet Medicine, Baibu-Ziwan, Cough Variant Asthma, Compatibility, Cytokines 不同配比组方的百部–紫菀药对