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Cell signalling pathways that mediate haematopoietic stem cell specification.pdf

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Cell signalling pathways that mediate haematopoietic stem cell specification

RC J L a A R R A A K H C B N W C t h s 1 hThe International Journal of Biochemistry Cell Biology 44 (2012) 2175– 2184 Contents lists available at SciVerse ScienceDirect The International Journal of Biochemistry Cell Biology journa l h o me page: www.elsev ier .com/ locate /b ioce l eview ell signalling pathways that mediate haematopoietic stem cell specification onathon Marks-Bluth, John E. Pimanda ? owy Cancer Research Centre and the Prince of Wales Clinical School, University of New South Wales, Sydney, NSW 2052, Australia r t i c l e i n f o rticle history: eceived 7 August 2012 eceived in revised form 9 September 2012 ccepted 10 September 2012 vailable online 17 September 2012 a b s t r a c t Haematopoiesis is one of the most intensively studied and best described systems in the body. However, knowledge of cell signalling pathways that drive haematopoietic stem cell (HSC) development and how they interact with each other and with transcription factors that specify HSCs is still rudimentary. In this review, we will highlight recent advances in the field relating to these questions and identify gaps that need to be filled. To this end, we will briefly describe the developmental ontogeny of HSCs and examineeywords: ematopoietic stem cells ell signalling mp otch in detail the cell signalling pathways that have been implicated in HSC specification. In conclusion we will discuss how this knowledge has led to the generation of blood cells in the laboratory and consider the implications of that advancement. ? 2012 Elsevier Ltd. All rights reserved.nt ontents 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .